血清脑钠肽和超敏C反应蛋白在2型糖尿病合并冠心病中的诊断价值  

Diagnosis value of serum BNP and hsCRP in patients with type 2 diabetic mellitus and coronary heart disease

作　　者：顾顺忠[1] 王德琴[2] 周永华[2] 颜永进[1] 丁宏胜[1] 王世亚[1] 

机构地区：[1]南通大学附属海安医院心血管病科,江苏省226600 [2]南通大学附属海安医院肾脏内分泌病科,江苏省226600

出　　处：《江苏医药》2015年第20期2412-2414,共3页Jiangsu Medical Journal

基　　金：南通市社会事业科技创新与示范计划项目(HS12905)

摘　　要：目的探讨血清脑钠肽(BNP)和超敏C反应蛋白(hsCRP)在2型糖尿病(T2DM)合并冠心病中的诊断价值。方法将64例T2DM合并冠心病患者(A组)按临床类型分为急性心肌梗死组(A1组,22例)、不稳定型心绞痛组(A2组,21例)和稳定型心绞痛组(A3组,21例);另选取64例T2DM不合并冠心病者作为对照(B组)。检测各组BNP、hsCRP和糖化血红蛋白(HbA1c)等水平。结果 A组患者HbA1c、胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、BNP[(216.00±31.53)ng/L vs.(29.00±4.20)ng/L]和hsCRP[(6.12±1.10)mg/L vs.(0.91±0.31)mg/L]水平均高于B组(P<0.01)。A1、A2和A3组间BNP和hsCRP水平差异亦有统计学意义(P<0.01)。A组患者血清BNP与hsCRP、HbA1c呈正相关(r=0.314、0.376,P<0.05),血清HbA1c与hsCRP表达亦呈正相关(r=0.576,P<0.01)。结论 T2DM合并冠心病患者血清BNP和hsCRP水平均明显增高。两者联合测定对诊断T2DM合并冠心病具有重要意义。Objective To explore the diagnosis value of serum brain natriuretic peptide（BNP）and high sensitivity C-reactive protein（hsCRP）in the patients with type 2diabetes mellitus（T2DM）and coronary heart disease（CHD）.Methods Sixty-four T2 DM patients with CHD（group A）were divided into acute myocardial infarction group（group A1,22cases）,unstable angina group（group A2,21cases）and stable angina pectoris group（group A3,21cases）.Sixty-four T2 DM patients without CHD were selected as the controls（group B）.Serum levels of BNP,hsCRP and HbA1 cwere detected in all groups.Results Serum levels of BNP[（216.00±31.53）ng/L vs.（29.00±4.20）ng/L],hsCRP[（6.12±1.10）mg/L vs.（0.91±0.31）mg/L],HbA1 c,TC and LDL-C were significantly higher in group A than those in group B（P〈0.01）.Serum levels of BNP and hsCRP were significantly different among groups of A1,A2 and A3（P〈0.05）.Serum BNP in group A was positively correlated with HbA1 cand hsCRP（r=0.376 and 0.314,P〈0.05）.Serum HbA1 c was positively correlated with hsCRP（r=0.576,P〈0.05）.Conclusion Serum BNP and hsCRP are increased in T2 DM patients with CHD.Combined determination of BNP and hsCRP has a great significance in the diagnosis of T2 DM patients with CHD.

关 键 词：脑钠肽 超敏C反应蛋白 2型糖尿病 冠心病 

分 类 号：R587[医药卫生—内分泌]