抗幽门螺杆菌治疗儿童腹型过敏性紫癜的临床疗效  

Clinical efficacy of anti-Helicobacter pylori therapy in Henoch-Schnlein purpura with gastrointestinal involvement in children

作　　者：李燕林[1] 王永清[1] 朱迪卿[1] 周益平[1] 

机构地区：[1]常州市第一人民医院(苏州大学附属第三医院)儿科,江苏省213000

出　　处：《江苏医药》2015年第20期2415-2416,共2页Jiangsu Medical Journal

摘　　要：目的探讨抗幽门螺杆菌(Hp)治疗儿童腹型过敏性紫癜(HSP)的疗效。方法腹型HSP患儿70例,联合应用13 C-尿素呼气试验及血清抗Hp抗体检测Hp。其中的45例Hp阳性的HSP患儿随机分为两组:对照组20例,给予抗组胺及大剂量维生素C等常规治疗;治疗组25例,在常规治疗基础上加用抗Hp三联疗法。比较两组临床疗效。结果腹型HSP患儿Hp感染率64.3%。治疗组总有效率88.0%,高于对照组的60.0%(P<0.05);治疗组复发率27.3%,低于对照组的75.0%(P<0.05)。结论与常规治疗比较,加用抗Hp三联疗法可提高腹型HSP临床疗效,降低复发率。Objective To investigate the clinical efficacy of anti-Helicobacter pylori（Hp）therapy in Henoch-Schnlein purpura（HSP）with gastrointestinal involvement in children.Methods Using the 13 C-urea breath test and serum Hp antibody test,Hp infection was examined in 70 HSP children with gastrointestinal involvement,of whom 45 cases were positive for Hp infection and then assigned into two groups.Twenty patients（group C）were treated with conventional treatments of anti-histamines and large dose of vitamine C and another 25patients（group A）were treated with additional triple therapy for anti-Hp infection.The clinical efficacy was compared between two groups.Results The Hp infection rate of HSP children with gastrointestinal involvement was 64.3%.The overall effectiveness rate was higher in group A than that in group C（88.0% vs.60.0%）（P〈0.05）.The recurrence rate of HSP after anti-Hp infection treatments was lower in group A than that in group C（27.3% vs.75.0%）（P〈0.05）.Conclusion Compared to conventional treatments,additional triple therapy for anti-Hp infection may improve clinical efficacy and reduce the relapse rate of HSP with gastrointestinal involvement in children.

关 键 词：过敏性紫癜 幽门螺杆菌 

分 类 号：R725[医药卫生—儿科]