β3肾上腺素能受体基因多态性与儿童肥胖关联性的 Meta 分析  

Meta analysis of the relationship between β3 - adrenergic receptor gene polymorphism and childhood obesity

作　　者：王红清[1] 徐佩茹 李敏[1] 刘新彩[1] 

机构地区：[1]新疆医科大学第一附属医院儿科,乌鲁木齐830054 [2]新疆维吾尔自治区循证医学研究所

出　　处：《中华实用儿科临床杂志》2015年第20期1569-1572,共4页Chinese Journal of Applied Clinical Pediatrics

摘　　要：目的：探讨β3肾上腺素能受体（β3-AR）基因 Trp64Arg 变异与儿童肥胖易感性的关联。方法通过计算机检索 PubMed、Web of Science、Springer Link、超星 Medlink、中国生物医学文献服务系统、万方、维普和 CNKI 数据库，检索1995年1月至2014年2月公开发表的关于β3-AR 基因多态性与儿童肥胖关联的病例对照研究。根据统一的纳入排除标准，筛选文献，应用 RevMan 5.1软件对各纳入文献进行异质性检验及效应值合并，同时进行敏感性分析和偏倚估计。结果共检索到相关文献162篇，最终纳入符合条件的文献9篇，其中肥胖儿童1494例，正常体质量儿童1623人。等位基因 T 与 C 比较，中国病例组与对照组间的差异有统计学意义（P 约0.05），同样 TC ＋ CC 与 TT 比较及 TC 与 TT ＋ CC 比较得到相似的结果；日本的研究结果与中国相似，但匈牙利病例组与对照组间的差异无统计学意义（P ﹥0.05）。各研究的敏感性分析比较稳定，且漏斗图形基本对称。敏感性分析和发表偏倚分析证实上述 Meta 分析结果是稳定和可靠的。结论 TC ＋ CC/ TT、TC/TT ＋ CC 基因型和 T/ C 等位基因均与中国、日本儿童肥胖的发生有关，但与匈牙利儿童肥胖的发生无明显相关。β3-AR 基因 Trp64Arg 变异与儿童肥胖遗传易感性存在地区差异性。Objective To investigate the relationship between β3 - adrenergic receptor（β3 - AR）gene poly-morphism and the susceptibility of occurrence in children obesity. Methods The database of PubMed,Web of Science,Springer Link,Medlink,SinoMed,Wanfang,VIP and CNKI were systematically browsed online. The study re-ports regarding β3 - AR associated with children obesity from January 1995 to February 2014 were included in the re-search. The data were extracted,evaluated and heterogeneity tested by using software RevMan 5. 1. Results A total of 162 related literature were retrieved,and 9 of them were eligible with 1 494 obese children and 1 623 normal children were included. Allele T compared with C,the differences between the study group and the control group were statistical-ly significant（P ＆lt; 0. 05）,the findings from the same TC ＋ CC compared to TT and TC compared with TT ＋ CC were similar. Japanese research findings were similar to those of China,but the differences between the study group and the control group had no statistical significance（P ﹥ 0. 05）in Hungary. The sensitivity analysis in each study was stable and the funnel graphics were basically symmetric. The results of sensitivity analysis and publication bias diagnostics demonstrated the reliability and stability of the Meta analysis. Conclusions TC ＋ CC/ TT,TC/ TT ＋ CC genotype and allele T/ C are related to the occurrence of childhood obesity in China,Japan,but there is no significant correlation with childhood obesity in Hungary. There are regional difference between β3 - AR gene polymorphism and genetic susceptibility to children obesity.

关 键 词：肥胖 Β3-肾上腺素能受体基因 儿童 META 分析 

分 类 号：R723.14[医药卫生—儿科]