501例药源性肾损伤分析  

Analysis of 501 Cases of Drug-induced Kidney Injury

作　　者：赵靓[1] 郭代红[1] 朱曼[1] 徐元杰[1] 马亮[1] 赵鹏芝[1] 蔡乐[1] 赵粟裕 王忠强[1] 

机构地区：[1]解放军总医院药品保障中心,北京100853

出　　处：《中国药物警戒》2015年第10期627-631,共5页Chinese Journal of Pharmacovigilance

基　　金：2014年全军后勤科研重点项目军队药品风险监测防控技术与支撑平台的研究(BWS14R039)

摘　　要：目的：探讨各类药物导致药源性肾损伤的规律和特点，为临床用药提供参考。方法从2009～2014年解放军药品不良反应监测中心数据库中检索出药源性肾损伤报告501例，对涉及的患者年龄、性别、药物类别、给药途径、时间、临床表现及转归等情况进行统计分析。结果501例药源性肾损伤中，女175例（34.93%），男326例（65.07%），平均年龄（54.14±21.99）岁，涉及197种药物，其中抗感染药所占比例最大，给药途径以静脉滴注为主，药品不良反应发生时间多在用药1周以内（72.45%），大部分患者预后良好，其中痊愈、好转406例（81.04%）。结论药源性肾损伤涉及药物种类较多，临床应提高对药源性肾损伤的认识，加强对高危人群及高危药物的预警防范。Objective To analyze the regular pattern and characteristics of drug-induced kidney injury and provide reference for the use of clinical drug. Methods 501 drug-induced kidney injury cases from 2009 to 2014 were collected from the database of PLA ADR monitoring center. Age and gender of patients, categories of suspected drugs, route of administration, occurrence time, clinical feature and prognosis were statistically analyzed. Results The 501 cases were composed of 175 female patients （34.93%） and 326 male patients （65.07%）. The average age of the patients was （53.48±21.99） years. The adverse drug reactions were caused by 197 kinds of drugs, among which the anti-infective drugs ranked first, with 221 related cases. Intravenous infusion was the primary administration route and the occurrence time of ADRs was mainly within one week. Most cases had good prognosis, with 356 cases （71.06%） cured or improved. Conclusion A wide category of drugs may cause drug-induced kidney injury. Therefore, much more attention should be paid on the high-risk drugs and high-risk groups.

关 键 词：药源性肾损伤 药品不良反应 统计分析 

分 类 号：R994.11[医药卫生—毒理学]