3-氯-1-(2-噻吩)丙酮的不对称催化氢化工艺的研究  

Study on asymmetric catalytic hydrogenation of 3-chloro-1-(2-thienyl) acetone

作　　者：刘娅静[1] 张贤龙[1] 吴光辉[1] 苏晓霞[1] 董小妹[1] 晁国库[1] 任宝东[1] 赵亚娟[1] 

机构地区：[1]温州大学化学与材料工程学院,浙江温州325035

出　　处：《化学工程师》2015年第10期4-8,共5页Chemical Engineer

基　　金：温州大学"学科提升战略"建设项目预研计划(No.316406125020301);浙江省科技厅公益项目(2013C31129)资助

摘　　要：利用铁基手性络合催化剂Fe Cl2(TPP)2[(1S,2S)-DPEN]/-γ-Al2O3对3-氯-1-(2-噻吩)丙酮进行催化加氢而制得抗抑郁药度洛西汀中间体(S)-3-氯-1-(2-噻吩)丙醇,与以往的方法相比,此方法不仅产率高且绿色环保。并探讨了温度、氢压和加氢时间对产物转化率以及选择性的影响。实验结果表明:温度在25℃,氢压在1.2MPa,反应时间在10h,3-氯-1-(2-噻吩)丙酮的转化率98%,(S)-3-氯-1-(2-噻吩)丙醇的e.e值为85%。For the synthesis of the antidepressant duloxetine intermediate （S） -3 - chloro -1 -（2 -thienyl ） propanol, a more efficient and environment protecting way has been developed through catalytic hydrogenation of 3-chloro-1-（2-thienyl）acetone in the presence of a chiralcomplexiron-basedcatalyst supported on A1203. The ef- fects of reaction temperature, hydrogen pressure, time of hydrogenation on the conversion rate and the product se- lectivity have been studied. The results show that when the temperature is 25℃ and the hydrogen pressure is 1.2 MPa, the conversion？rate of 3-chloro-1-（2-thienyl）acetone is 98% and the e.e.% of （S） -3- chloro-1- （2-thienyl） propanol is 85% in ten hours.

关 键 词：不对称加氢 铁基手性催化剂 3-氯-1-(2-噻吩)丙酮 (S)-3-氯-1-(2-噻吩)丙醇 

分 类 号：O643[理学—物理化学]