铁包金按摩膏对腰椎间盘突出症大鼠腰背脊神经根中PLA2影响的实验研究  

Research of Gold Plated Iron Massage Cream on PLA2 in Intervertebral Disc Segmental Spinal Nerve Root of Rat Models of Lumbar Disc Herniation

作　　者：蔡萍[1] 戎宽[1] 杨惠[2] 胡余飞[2] 匡建军[1] 

机构地区：[1]湖南省中医药研究院,湖南长沙410006 [2]湖南中医药大学,湖南长沙410208

出　　处：《新中医》2015年第11期194-196,共3页New Chinese Medicine

基　　金：湖南省科技厅(2013SK3108);杨永华全国名老中医药专家传承工作室

摘　　要：目的:观察铁包金按摩膏对腰椎间盘突出症(LDH)大鼠突出的椎间盘节段脊背神经根中磷脂酶A2(PLA2)的调节作用。方法:健康SD大鼠48只,采用随机数法将大鼠分为空白组、铁包金组、狗皮膏组和模型组,每组12只。采用注射法建立非压迫型腰椎间盘髓核突出大鼠模型,造模成功后分别对各组进行相应处理:空白组模拟手术后正常饲养;铁包金组予铁包金按摩膏局部治疗;狗皮膏组采用狗皮膏外贴治疗;模型组给予凡士林局部对比治疗;分别测量治疗1周、2周、3周后各组LDH大鼠相应椎间盘节段脊背神经根中PLA2的活性并对数据进行统计学分析。结果:给药1周、2周、3周,各组PLA2活性均高于空白组(P<0.05)。给药2周,铁包金组、狗皮膏组均低于模型组(P<0.05);给药3周铁包金组、狗皮膏组PLA2均低于给药1周(P<0.05)。结论:铁包金按摩膏具有降低非压迫性髓核突出大鼠模型相应节段脊背神经根中PLA2活性的作用。Objective. To Investigate the regulating effect of Gold plated iron massage cream on Phospholipase A2 （PLA2） in intervertebral disc segmental spinal nerve root of rat models of lumbar disc herniation（LDH）. Methods： Forty healthy SD rats, using random numbers, were divided into the blank group, gold prated iron massage cream（GP）group, dog-skin plaster （DP） group and the moder group, 12 cases in each group. Injection was adopted to establish the non-pressure lumbar nucleus pulposus prominent rat model. After the success of building models, each group was treated corresponding processing respectively： The GP group with local treatment of GP, the DP group with DP stick, the model group with Vaseline treatment. The blank group normally fed without injection. The active of PLA2 in intervertebral disc segmental spinal nerve root was detected 1-week, 2-week, 3-week after treatment. Results. The active of PLA2 in each group 1-week, 2-week, 3-week after treatment was higher than that in the blank group（P 〈 0.05）. In GP group and DP group, the active of PLA2 2-week, 3-week after treatment was lower than that in the model group. That 3-week in GP group and DP group after treatment was lower than that 1-week in GP group and DP group（P 〈 0.05）. Conclusion： GP can effectively decrease PLA2 in non-pressure lumbar nucleus pulposus prominent rat model.

关 键 词：腰椎间盘突出症 铁包金按摩膏 大鼠 磷脂酶A2(PLA2) 

分 类 号：R285.5[医药卫生—中药学]