探讨MAPKs和PI3K信号通路在胃癌中的作用及意义  

The Role and significance of MAPKs and PI3K Pathways in Gastric Cancer

作　　者：王凤[1] 吴志峰[1] 黄秀清[1] 林丽琳[1] 翁剑武[1] 刘彪[1] 陈秀娇[2] 徐丽[3] 

机构地区：[1]莆田学院 [2]莆田学院基础医学院病理教研室 [3]莆田学院基础医学院生理教研室,福建莆田351100

出　　处：《牡丹江医学院学报》2015年第5期5-8,共4页Journal of Mudanjiang Medical University

基　　金：福建省大学生创新创业训练计划项目(201311498017);度莆田学院大学生创新创业训练计划项目(CXCY1303);福建省大学生创新创业训练计划项目(201411498004)

摘　　要：目的通过检测胃癌及癌旁组织中Akt,ERK1/2,Bcl-2及NF-κB的表达,探讨MAPKs和PI3K信号通路之间的关系及其在胃癌发展过程的作用。方法应用免疫组织化学技术检测62对胃癌及癌旁组织中Akt,ERK1/2,Bcl-2和NF-κB蛋白的表达情况。结果胃癌中Akt,ERK1/2,Bcl-2及NF-κB蛋白的阳性表达率均高于其癌旁组织,差异具有统计学意义(P均<0.05)。胃癌组织Akt蛋白表达与ERK1/2蛋白表达呈正相关(rs=0.272,P=0.026),结论 MAPKs信号通路、PI3K信号通路激活与胃癌的发生发展密切相关。Objective To investigate the expressions of Akt,ERK1 /2,Bcl- 2 and NF- κB in gastric cancer and adjacent tissues,and discuss the relationship between MAPKs and PI3 K pathways and their role in the development of gastric cancer. Methods Expressions of Akt,ERK1 /2,Bcl- 2 and NF- κB proteins were examined in 62 gastric cancer and adjacent tissues by immunohistochemical technique. Results The positive rate of Akt,ERK1 /2,Bcl- 2 and NF- κB proteins in gastric cancer were significantly higher than those in it＇s adjacent tissues,the difference has statistically significant（ P〈0. 05）. Expression of Akt and ERK1 /2 proteins were in a positive correlation（ rs = 0. 282,P = 0. 026）. Conclusion The activation of MAPKs and PI3 K pathways is closely related to the development of gastric cancer.

关 键 词：MAPK通路 PI3K通路 胃癌 

分 类 号：R37[医药卫生—病原生物学]