2型糖尿病肾脏疾病患者血清SAA-LDL水平与oxLDL的关系研究  

Relationship between Serum Amyloid A-low-density Lipoprotein Complex and Oxidized Low Density Lipoprotein in Diabetic Kindney Disease of Type 2 Diabetes

作　　者：张高明[1] 张国明[1] 郭绪晓[2] 杨莉[1] 马小波[1] 韩洪波[1] 

机构地区：[1]沭阳县人民医院,江苏宿迁223600 [2]山东中医药大学附属医院检验科,山东济南250011

出　　处：《牡丹江医学院学报》2015年第5期18-20,共3页Journal of Mudanjiang Medical University

摘　　要：目的研究2型糖尿病肾脏疾病(T2DKD)病人血清中血清淀粉样蛋白A-低密度脂蛋白(serum amyloid A-low-density lipoprotein complex,SAA-LDL)水平变化及其与氧化型低密度脂蛋白(oxidized low density lipoprotein,ox LDL)的相关关系。方法按尿微量清蛋白/尿肌酐比(Urine Albumin-to-Creatinine Ratio,UACR)水平将260例T2DM病人分3组:单纯糖尿病(SD组,n=80),早期糖尿病肾脏疾病(ED组,n=86)和临床糖尿病肾脏疾病(CD组,n=94),另选体检中心体检健康者作为对照(NC组,80例),分别测定各组血清空腹血糖(FGP),糖化血红蛋白(Hb A1c),超敏C反应蛋白(hs CRP),ox LDL,SAA-LDL,低密度脂蛋白质胆固醇(LDL-C)等相关指标并进行相关分析。结果 SD组,ED组,CD组血清SAA-LDL和ox LDL水平较对照组升高并随清蛋白尿水平升高而增加。SAA-LDL与hs-CRP,ox LDL正相关(r=0.871,P<0.05;r=0.762,P<0.05)。结论 T2DKD患者SAA-LDL水平明显升高,SAA-LDL与hs-CRP,ox LDL正相关,SAA-LDL可能促进T2DKD发生,发展。Objective To study the relationship between serum amyloid A- low- density lipoprotein complex（ SAA- LDL）and oxidized Low density Lipoprotein（ ox LDL） in diabetic kindney disease of type 2 diabetes. Methods SAA- LDL and ox LDL of blood serum were measured by double antibody enzyme linked inmmunosorbent assay. Results Compare with control group,serum level of SAA- LDL and ox LDL were distinctly lower[（ 28. 56 ± 3. 24,39. 56 ± 6. 78,51. 23 ± 9. 12 vs 15. 11 ± 2. 14,P〈0. 05）,（ 396. 19 ± 18. 46,475. 34 ± 29. 17,599. 10 ± 35. 21 vs 289. 22 ± 14. 32,P〈0. 05） ],and correlation analysis suggested that serum of SAA- LDL were positively correlated with ox LDL and CRP（ r = 0. 871,P〈0. 05; r = 0. 762,P〈0. 05）. Conclusion The serum SAA- LDL of level was distinctly higher,and was positively correlated with ox LDL and CRP,and is closely related to the diabetic kindney disease of type 2 diabetes.

关 键 词：2型糖尿病 肾脏疾病 淀粉样蛋白A-低密度脂蛋白复合物 氧化低密度脂蛋白 尿清蛋白 尿蛋白 

分 类 号：R54[医药卫生—心血管疾病]