5,6-二甲基-2,3-吡嗪二甲酰胺-镍配合物的制备及其抗菌活性研究  

Study on Synthesis and Antibacterial Activity of 5,6-dimethyl-2,3-pyrazinedimethylformamide-Ni

作　　者：文丽君[1] 王英[2] 李海霞[1] 李娟[1] 

机构地区：[1]海南医学院药学院,海南海口571199 [2]海南医学院热带医学与检验医学院,海南海口571199

出　　处：《广东化工》2015年第20期53-54,57,共3页Guangdong Chemical Industry

基　　金：海南医学院科研培育基金项目(HY2013-23);海南省自然科学基金项目(20152040)

摘　　要：以2,3-二甲基-5,6-二氰基吡嗪为原料,稀碱条件下不完全氧化得到配体5,6-二甲基-2,3-吡嗪二甲酰胺,再与醋酸镍在弱碱条件下合成5,6-二甲基-2,3-吡嗪二甲酰胺-镍配合物,通过红外光谱、紫外光谱、差热-热重分析对配合物进行表征。采用牛津杯法预试验及试管二倍稀释法研究配体5,6-二甲基-2,3-吡嗪二甲酰胺及其配合物的抗菌活性。结果表明5,6-二甲基-2,3-吡嗪二甲酰胺-镍配合物表现出一定的抑菌和杀菌作用,而配体没有明显的抑菌杀菌作用。5,6-dimethyl-2,3-pyrazinedimethylformamide-Ni（Ⅱ） was prepared with using Ni（CH3COO）2 and 5,6-dimethyl-2,3-pyrazinedimethylformamide, which has been prepared with 5,6-dimethyl-2,3-pyrazinecarbonitrile as raw material via hydrolysis in dilute basic solution using H2O2 as oxidant. The compex was characterized by UV spectra, IR spectra and TGA spectra. The antibacterial activity of 5,6-dimethyl-2,3-pyrazinecarbonitrile and the complex were compared by Oxford cup method and tube double dilution method. The results showed that 5,6-dimethyl-2,3-pyrazinedimethylformamide-Ni（Ⅱ） complexes has bacteriostatic and bactericidal effect. But not obvious inhibitory effect by 5,6-dimethyl-2,3-pyrazinedimethylformamide.

关 键 词：5 6-二甲基-2 3-吡嗪二甲酰胺 配合物 合成 抗菌活性 

分 类 号：TQ[化学工程]