不同剂量西地那非治疗新生儿肺动脉高压的疗效  

The curative effect of different dose of sildenafil on treating pulmonary hypertension of newborn

作　　者：周秀英[1] 王继萍[1] 

机构地区：[1]新疆阿克苏地区第一人民医院,新疆阿克苏843000

出　　处：《农垦医学》2015年第1期58-59,共2页Journal of Nongken Medicine

摘　　要：目的:分析新生儿肺动脉高压患儿服用不同剂量西地那非的临床效果。方法:选取近两年100例在我院接受治疗的肺动脉高压患儿,平均分为对照组和试验组,每组50人,对照组给予1.0mg/kg西地那非,试验组给予2.0mg/kg西地那非,对两组患儿的临床状况以及肺动脉压力、二氧化碳动脉血氧分压对比并研究。结果:经过治疗后,试验组患儿治疗后肺动脉压力(25.00±4.5)明显低于对照组患儿肺动脉压力(28.10±4.2);试验组二氧化碳血氧分压(35.30±4.4)明显低于对照组二氧化碳血氧分压(48.10±5.6),两组差异具有统计学意义(<0.05)。结论:对于新生儿肺动脉高压,西地那非剂量有效增加,肺动脉压力降低效果更加明显,呼吸困难及发绀症状有效缓解,值得临床广泛应用并加以推广。Objective： To observe the clinical effect of taking different dose of sildenafil on treating pulmonary hypertension of newborn.Method： Selected 100 pulmonary hypertension of newborns treated in our hospital for the past two years,divided into control group and experiment group on average,50 for each group,the control group was given 1.0mg/kg sildenafil,the experiment group was given 2.0mg/kg sildenafil,contrasted and studied two groups＇ clinical condition、pulmonary arterial pressure、arterial blood oxygen partial pressure of carbon dioxide.Result： The experiment group＇s pulmonary arterial pressure（25.00±4.5）is obviously lower than that of control group（28.10±4.2）after treatment,the same as the blood oxygen partial pressure of carbon dioxide,the difference has statistical significance.Conclusion：To pulmonary hypertension of newborns,if the dose of sildenafil is effectively increased,the effect is more obvious in reducing pulmonary arterial pressure,can effectively relieve dyspnea and cyanosis symptoms,deserved to be extensively applied and popularized in clinic.

关 键 词：新生儿 西地那非 肺动脉高压 临床效果 

分 类 号：R722.1[医药卫生—儿科]