痛风性关节炎发病的危险因素  

Case-control study of risk factors for acute attack of gout

作　　者：叶德邵 徐霞[2] 张兰玲[2] 施冶青[2] 高洁[2] 赵东宝[2] 

机构地区：[1]解放军180医院风湿免疫科,福建泉州362000 [2]第二军医大学附属长海医院风湿免疫科,上海200433

出　　处：《东南国防医药》2015年第5期461-463,共3页Military Medical Journal of Southeast China

基　　金：上海市卫生系统优秀学科带头人新百人计划基金(XBR2011006)

摘　　要：目的探讨痛风性关节炎发病的危险因素、常见体检和生化检查项目对早期诊断痛风性关节炎发病的意义,为预防痛风发病提供依据。方法采用配对病例对照研究,以2014年6-12月间发生痛风并到上海某三甲医院门诊就诊的104例为痛风组,以未发过痛风且性别、年龄等匹配的104例体检者为对照组。收集身高、体重、血压等一般资料,并进行血生化检查,将检查结果进行多因素条件Logistic回归分析。结果痛风性关节炎患者首发年龄为（43.72±0.93）岁,95%可信区间为41.87-45.57。发病具有明显性别差异,男∶女为16.3∶1。高尿酸血症、高胆固醇血症、高三酰甘油血症、高舒张压为痛风发病的主要相关因素,优势比为29.321（P〈0.001）、25.738（P=0.002）、10.179（P〈0.001）、3.270（P=0.042）。结论痛风性关节炎常发生于40岁以上男性。高尿酸血症、高胆固醇血症、高三酰甘油血症、高舒张压4个因素为痛风发病的危险因素。Objective To analyze the risk factors related to acute attack of gout and to provide advise to prevent the patient from the acute attack of the gout. Methods The research introduced a 1： 1 matched case-control study. 104 patients with an attack of acute gout were included as the patient group and 104 healthy people with matched age and gender as the control group. The general data such as the height,the body mass,the blood pressure of the two groups were recorded and the blood biochemistry test of the two groups were taken. Multivariate logistic regression analysis was adopted to analyse the data. Results The average age of the patients with gout arthritis was（ 43. 72 ± 0. 93） years old,and the 95% confidence interval was 41. 87- 45. 57. The difference between the gender is obvious with ratio was 16. 3 ∶ 1（ the male versus the female）. Uric acid,total cholesterol,triglyceride and diastolic blood pressure were the four factors that influence the acute attack of gout. The relative risk was 29. 321（ P〈 0. 001）,25. 738（ P = 0. 002）,10. 179（ P 〈0. 001） and 3. 270（ P = 0. 042） respectively. Conclusion A man in his forties is easily attacked by gout. Hyperuricemia,high blood level of total cholesterol,triglyceride and diastolic blood pressure are the four risk factors for acute attack of gout.

关 键 词：痛风 危险因素 病例对照研究 LOGISTIC回归模型 

分 类 号：R589.7[医药卫生—内分泌]