2型糖尿病患者尿微量白蛋白与左室肥厚的关系  

The relationship between microalbuminuria and left ventricular hypertrophy in type 2 diabetes

作　　者：刘蓉[1] 张丹[1] 杨玲[1] 

机构地区：[1]常州市第七人民医院内分泌科,江苏常州213011

出　　处：《东南国防医药》2015年第5期506-507,543,共3页Military Medical Journal of Southeast China

摘　　要：目的探讨2型糖尿病患者尿微量白蛋白水平与左心室肥厚的关系。方法 2型糖尿病患者136例,接受超声心动图检查,计算左室质量指数(LVMI),采用LVMI男性>125 g/m2、女性>110 g/m2作为左心室肥厚(LVH)的标准。测定24 h尿白蛋白水平,分为正常白蛋白尿组、微量白蛋白尿组、大量白蛋白尿组,比较三组LVMI值及LVH发生率,将LVMI与24 h尿白蛋白水平进行相关性分析。结果随24 h白蛋白水平增高,2型糖尿病患者LVMI升高,左室肥厚发生率增加,LVMI与24 h尿白蛋白水平呈正相关关系(r=0.211,P<0.05)。结论 2型糖尿病患者出现尿微量白蛋白时发生左室肥厚风险增加,有助于早期识别2型糖尿病患者心血管疾病的发生。Objective To study the relationship between microalbuminuria and left ventricular hypertrophy in type 2 diabetes（ T2DM）. Methods 136 patients diagnosed with T2 DM accepted color Doppler echocardiogram. Calculated the left ventricular mass index（ LVMI）. LVH was defined as follows： LVMI 〉125 g / m^2 for men and LVMI 〉110 g / m^2 for women. According to the 24 h Urinary albumin levels,they were divided into three groups： normal urinary albumin group,microalbuminuria group and macroabuminuria group. Compare LVMI values and rate of LVH among three groups. LVMI and 24 h urinary albumin level was explored by correlation analysis. Results With the increase of 24 h protein level,the level of LVMI increased in patients with type 2 diabetes,and the incidence of left ventricular hypertrophy increased. The level of LVMI was positively correlated with the level of 24 h urinary albumin（ r =0. 211,P〈0. 05）. Conclusion The risk of the LVH in type 2 diabetes mellitus increased when present with albuminuria. Measure albuminuria may help to identify cardiovascular disease in patients with type 2 diabetes mellitus.

关 键 词：2型糖尿病 左室肥厚 尿微量白蛋白 

分 类 号：R587.1[医药卫生—内分泌]