局部注射辛伐他汀修复轻中度不稳定肱骨骨折:对骨愈合及骨密度的影响  

Local injection of simvastatin for repair of mild-to-moderate unstable humeral fractures:effects on bone healing and bone density

作　　者：刘建[1] 田宝方[1] 王文珠[2] 郑卫东[3] 冯立[1] 杜宝印[1] 田大为[2] 

机构地区：[1]济宁市第一人民医院急诊外科,山东省济宁市272100 [2]湖北医药学院附属东风医院,湖北省十堰市442000 [3]济宁市第一人民医院麻醉科,山东省济宁市272100

出　　处：《中国组织工程研究》2015年第37期5933-5937,共5页Chinese Journal of Tissue Engineering Research

基　　金：湖北省教育厅课题(B20112102):课题名称:计算机辅助设计管状骨骨折复位器导向器及生物力学测试~~

摘　　要：背景:研究显示疏松骨骼单次注射小剂量辛伐他汀可显著改善骨骼微结构,促进股骨髁部骨小梁改建。目的:临床验证局部注射辛伐他汀增强轻中度不稳定肱骨骨折预后效果的影响。方法:选取轻中度不稳定肱骨骨折患者93例,采用抛硬币法随机分成注射组(49例)和常规组(44例)。常规组采用常规物理疗法治疗,注射组在给予常规物理治疗的基础上,局部注射辛伐他汀疗法治疗,对比分析两组患者骨密度及骨折愈合时间。结果与结论:两组患者治疗后2周内骨密度值差异无显著性意义(P>0.05);治疗结束后的一两个月,注射组患者骨密度值明显高于常规组(P<0.05)。注射组并发症出现率、关节功能恢复优良率均优于常规组,住院天数明显少于常规组。结果说明,临床上对轻中度不稳定肱骨骨折患者在给予常规物理治疗的基础上,同时采用局部注射辛伐他汀疗法治疗,能缩短骨折愈合时间、增加骨密度值,对提升患者骨折预后质量具有积极影响。BACKGROUND;Studies have shown that a single injection of small-dose simvastatin can significantly improve bone microstructure and promote trabecular bone remodeling of the femoral condyle after osteoporosis.OBJECTIVE;To investigate the effect of local single injection of simvastatin on the prognosis of mild-to-moderate unstable humeral fractures.METHODS;A total of 93 patients with mild-to-moderate unstable humeral fracture were selected and randomized into injection group（49 cases） and normal group（44 cases）.The normal group received normal physical therapy,and the injection group underwent local single injection of simvastatin based on the physical therapy.Bone mineral density and healing time were compared between two groups.RESULTS AND CONCLUSION;There was no difference in the bone mineral density between the two groups within 2 weeks after treatment（P〉0.05）,but the bone mineral density was significantly higher in the injection group than the normal group at 1-2 months after treatment（P〈0.05）.In addition,the injection group was superior to the normal group in the following aspects;incidence of complications,excellent-good rate of jointfunction recovery,and hospital stay.These findings indicate that the local injection of simvastatin based on conventional physical therapy can shorten the time of fracture healing,increase bone mineral density and improve the prognosis of patients with mild-to-moderate unstable proximal humeral fractures.

关 键 词：组织构建 骨组织工程 辛伐他汀 轻中度不稳定肱骨骨折 预后效果 组织工程 

分 类 号：R318[医药卫生—生物医学工程]