非手术修复膝骨关节炎的评价:量表与生物力学方法  

Non-surgical therapy for knee osteoarthritis:effectiveness evaluation using scale and biomechanical methods

作　　者：刚嘉鸿 宓轶群[1] 张永亮[1] 王华敏[1] 

机构地区：[1]上海交通大学附属第六人民医院,上海市200233

出　　处：《中国组织工程研究》2015年第37期6017-6023,共7页Chinese Journal of Tissue Engineering Research

基　　金：上海市卫生和计划生育委员会;上海市中医药发展办公室上海市中医药三年行动计划项目(zy3-pcpy-3-1018);上海市卫生局中医药科研基金(2012J012A)资助~~

摘　　要：背景:非手术疗法治疗膝骨关节炎疗效确切,但是缺乏科学合理的疗效评价系统。目的:详细阐述近5年来非手术疗法治疗膝骨关节炎临床疗效评价方法。方法:查阅Pub Med、WOK、CNKI、维普、万方等相关数据库,查找关于膝骨关节炎非手术疗法临床疗效评价方法的文献,对资料进行初审,剔除无关文献,保留与非手术疗法治疗膝骨关节炎临床疗效评价方法相关的研究文献,排除重复研究及不典型报道。结果与结论:共纳入42篇符合标准文献,包括中文文献28篇,英文文献14篇。经分析得出:膝骨关节炎非手术疗法可以有效改善膝关节功能,提高患者生活质量,具有确切的疗效和较好的经济效益。因此探索科学、合理的临床疗效评价方法,用以指导最优临床疗法的选择,进一步提高非手术疗法治疗膝关节骨性关节炎的疗效和可推广性,具有重要意义。以量表为主的评价方法简便易行,具有可实践性,但是单一量表评价方法存在主观性较强等不足。生物力学、影像学检查等疗效评价方法客观、可信度高,且有准确、无创等优势。在疗效评价体系中,应该多引入主观量表观察与客观指标相结合的评价方式,根据不同侧重,选取相应的疗效评价方法。BACKGROUND;Studies have shown that the non-surgical therapy for knee osteoarthritis is exactly effective,but there is a lack of scientific and rational evaluation system.OBJECTIVE;To review the evaluation methods of non-surgical therapy for knee osteoarthritis in recent 5 years.METHODS;A computer-based retrieval of Pub Med,WOK,CNKI,VIP,Wanfang databases was performed to find literature related to the evaluation methods of non-surgical therapy for knee osteoarthritis.All data were primarily screened to exclude irrelevant literature.Those literatures about the evaluation methods of non-surgical therapy for knee osteoarthritis were included.Repetitive studies and untypical reports were excluded.RESULTS AND CONCLUSION;Totally 42 articles were collected,including 28 in Chinese and 14 in English.The analysis results showed that the non-surgical treatment for knee osteoarthritis can improve knee function and the quality of life in patients,and have an exact effect and a good economic benefit.Therefore,exploring a scientific and reasonable evaluation method to guide the choice of clinical treatment for knee osteoarthritis is greatly significant,which can improve the efficacy of non-surgical therapy for knee osteoarthritis.Scale-based evaluationmethod is simple and practical,but the presence of a single scale has a lack of objectivity.The method of biomechanics or imaging has the advantages of objective,highly reliable,accurate,non-invasive and so on.In the future therapeutic evaluation system,the combination of subjective scale observation and objective indicators should be more recommended,and the evaluation methods of non-surgical therapy for knee osteoarthritis should be selected appropriately based on the difference of clinical therapy and effect.

关 键 词：组织构建 骨组织工程 膝关节骨性关节炎 非手术疗法 临床疗效评价 量表 影像学 组织工程 

分 类 号：R318[医药卫生—生物医学工程]