薯蓣丸加减方对鼻咽癌放疗患者EB病毒的影响  

Effects of Modified Dioscorea Pills Prescription on EB virus in Nasopharyngeal Carcinoma Patients Receiving Radiotherapy

作　　者：刘百祥[1] 肖旭平[1] 严文辉[2] 叶剑荣[1] 肖瑶[1] 张昱 周建波[1] 邓坦[1] 刘劲[1] 张薇薇[1] 

机构地区：[1]湖南省人民医院,湖南长沙410005 [2]湖南省第二人民医院,湖南长沙410007

出　　处：《湖南中医药大学学报》2015年第9期58-61,共4页Journal of Hunan University of Chinese Medicine

基　　金：湖南省中医药管理局重点科研项目(201226)

摘　　要：目的观察薯蓣丸加减方对鼻咽癌放疗患者EB病毒的影响。方法将60例鼻咽癌患者随机分为观察组和对照组各30例,观察组在放疗开始第1天给予口服薯蓣丸加减方治疗,对照组在开始放疗第1天给予康复新液治疗。观察两组治疗前后临床疗效、患者生活质量及EB病毒DNA水平。结果治疗后观察组临床疗效及中医症候疗效均优于对照组(P<0.05);两组生活质量均有明显改善(P<0.05),观察组改善更为显著(P<0.01);血浆EBV-DNA水平均较治疗前下降(P<0.05),观察组下降更为显著(P<0.01)。结论薯蓣丸加减方对鼻咽癌放疗患者有较好的治疗作用,可提高患者生活质量,其作用机制可能与降低鼻咽癌患者血浆EBV-DNA水平有关。Objective To observe the effect of modified Dioscorea Pills prescription on EB virus in nasopharyngeal carcinoma patients receiving radiotherapy. Methods 60 cases of patients with nasopharyngeal carcinoma（NPC） were randomly divided into the observation group and the control group, 30 cases in each group. The observation group was given modified Dioscorea Pills prescription for treatment on the first day receiving radiotherapy, the control group was given Kangfuxin on the first day. The clinical curative effect, quality of life and EB virus DNA levels in two groups were observed before and after treatment. Results After treatment, the clinical curative effect and TCM syndrome efficacy of observed group were better than control group（P〈0.05）; The level of the quality of life in the two groups was improved obviously（P〈0.05）; The improvement in observation group was more significant（P〈0.01）. The plasma EBV-DNA levels of two groups were lower than before（P〈0.05）, the observation group decreased significantly（P〈0.01）. Conclusion Modified Dioscorea Pills prescription show good effect in treatment of patients with NPC and can improve the quality of life of patients,and its mechanism may be associated with the decrease of plasma EBV-DNA levels.

关 键 词：鼻咽癌 放疗 薯蓣丸加减方 EB病毒 薯蓣 生地黄 天花粉 

分 类 号：R273[医药卫生—中西医结合] R739.6[医药卫生—中医肿瘤科]