生殖器疱疹及其疫苗的研究进展  

Progress in research on genital herpes and its vaccines

作　　者：戴橄[1] 刘水平[1] 

机构地区：[1]中南大学基础医学院微生物学系,长沙410078

出　　处：《国际生物制品学杂志》2015年第5期230-233,238,共5页International Journal of Biologicals

摘　　要：生殖器疱疹由单纯疱疹病毒（herpes simplex virus,HSV）感染所致,在世界范围内广泛流行.HSV可在宿主体内建立终身潜伏感染,并引起严重的复发性疾病.此外,HSV感染还能明显增加HIV感染的机率.虽然目前抗HSV药物有一定作用,但是不能防止潜伏HSV复活.因此,亟需研制有效的疫苗来控制HSV感染、限制疾病传播和复发.此文对生殖器疱疹的病原学、流行病学及疫苗的研究进展做一综述.Genital herpes, a widespread sexually transmitted disease, is caused by herpes simplex virus （HSV） infection.HSV can establish lifelong latent infection in the host and cause severe and recurrent diseases.In addition, HSV infection significantly increases the risk of HIV infection.Although antiHSV drugs have some effects, they are not capable of preventing reactivation of latent HSV.Therefore, it is urgent to develop effective vaccines to control HSV infection, and limit spread and relapse of the disease.In this paper, the etiology and epidemiology of genital herpes and development progress of genital herpes vaccines are reviewed.

关 键 词：单纯疱疹病毒疫苗 疱疹 生殖器 疱疹病毒1型 人 疱疹病毒2型 人 

分 类 号：R752.1[医药卫生—皮肤病学与性病学]