NRP-1在子宫内膜癌及子宫内膜异位症中的表达及意义  

Expression of NRP-1 in Ectopic and Eutopic Endometrium of Women with Endometriosis/Endometrial Carcinoma

作　　者：胡蓉[1] 石婷[1] 刘文涓[1] 张小琼[1] 张迪娜 

机构地区：[1]中南大学湘雅医院妇产科,湖南长沙410008

出　　处：《肿瘤药学》2015年第5期339-343,共5页Anti-Tumor Pharmacy

基　　金：湖南省科技厅社会发展支撑计划项目(2014SK3138)

摘　　要：目的探讨神经纤毛蛋白-1(NRP-1)在子宫内膜异位症(内异症)患者异位及在位子宫内膜组织、子宫内膜癌组织中的表达及其意义。方法 36例卵巢子宫内膜异位囊肿患者、12例子宫内膜癌患者作为研究组,30例非内异症患者作为对照组。采用免疫组化技术,检测内异症患者在位子宫内膜及卵巢异位囊肿组织、子宫内膜癌组织、非内异症患者子宫内膜中NRP-1的表达情况。结果 (1)所有异位内膜、内膜癌组织中均可检测到NRP-1的表达。(2)内异症患者在位子宫内膜组织中NRP-1的表达强度低于同期对照组正常子宫内膜(P<0.05),且丧失正常子宫内膜表达的周期性变化。(3)内异症患者异位子宫内膜组织、内膜癌组织中NRP-1的表达强度高于在位子宫内膜(P<0.05),无正常内膜表达的周期性变化。结论内异症患者异位子宫内膜、子宫内膜癌组织中NRP-1的表达可能与其血管化程度有关;在位子宫内膜组织中NRP-1表达水平的减少,可能与内异症的生物学行为有关。Objective To study the expression of neuropilin-1 （NRP-1） in endometriosis and endometrial carcinoma. Method Thirty-six cases of ovary endometriosis and twelve cases of endometrial carcinoma were selected as study group, and 30 cases of non-endometriosis served as control group. Immunohistochemistry was used to detect the expression of NRP-1 in the eutopic and ectopic endometrium of endometriosis group, the lesions of endometrial carcinoma group and the endometrium of control group. Results （1） NRP-1 was expressed in ectopic and eutopic endometrium and endometrial carcinoma samples. （2） The NRP-1 expression level in eutopic endometrium of endometriosis patients was significantly lower than in endometrium of control group at the same phrase. The normal significant menstrual cyclical variations were absent in eutopic endometrium of endometriosis patients. （3） The NRP-1 expression levels were higher in ectopic endometrium of endometriosis patients and endometrial carcinoma lesions than in eutopic endometrium （P〈0.05）. The normal significant menstrual cyclical variations in endometrial NRP-1 were also absent. Conclusion The abnormal expression of NRP-1 may contribute to the altered angio-genesis in endometriosis and endometrial carcinoma. The downregulation of NRP-1expression in eutopic endometrium may have correlation with the biological behavior of endometriosis.

关 键 词：卵巢子宫内膜异位症 子宫内膜癌 NRP-1 血管生成 

分 类 号：R711.71[医药卫生—妇产科学]