聚酰胺树脂纯化银杏总内酯的工艺研究  

Study on Purification Technology for Ginkgolides in Ginkgo biloba L. with Polyamide Resin

作　　者：李雪峰[1,2] 徐振秋[1,2] 刘俊超[1,2] 王雪[1,2] 刘莉莉[1,2] 杨绪芳[1,2] 萧伟[1,2] 

机构地区：[1]江苏康缘药业股份有限公司,连云港222001 [2]中药制药过程新技术国家重点实验室,连云港222001

出　　处：《药学与临床研究》2015年第4期344-346,共3页Pharmaceutical and Clinical Research

基　　金：科技部重大新药创制现代中药创新集群与数字制药技术平台(2013ZX09402203)

摘　　要：目的:研究银杏总内酯的聚酰胺纯化工艺。方法:以树脂型号、上样量、洗脱溶剂、上样液浓度、柱径高比等为研究对象,进行工艺优化。结果:选择聚酰胺树脂,最佳上样提取物质量与柱体积比1∶50,洗脱溶剂为纯化水,径高比为1∶6,洗脱量2.5倍柱体积的纯化工艺,进行银杏总内酯纯化,其纯度达到70%以上。结论:纯化工艺操作简单,成本低廉,精制效果突出,有较高的工业生产应用价值。Objective: To investigate the purification technology of ginkgolides from Ginkgo biloba L. Methods: With the content of ginkgolides as the index, resin type, sample volume and concentration, elu-tion solvent and the rate of column diameter to height were selected as technique parameters. Results: The optimum purification condition was as follows: polyamide resin, sample weight vs column volume 1∶50, col-umn diameter vs height 1∶6 and 2.5 times column volume of elution volume, then the purity of ginkgolides can reach more than 70%. Conclusion: Owing to simple operation, low cost and high purity, the above method for purification of ginkgolides can be widely used in practice.

关 键 词：聚酰胺树脂 银杏总内酯 纯化 

分 类 号：TQ460.6[化学工程—制药化工]