Clonidine alleviate cerebral ischemia/reperfusion injury by regulation of phospho-NMDAR2B, phospho-NMDAR1 and NMDAR2A  

出　　处：《中国药理学通报》2015年第B11期160-160,共1页Chinese Pharmacological Bulletin

摘　　要：To investigate the underlying mechanism of the protection on cerebral ischemia of α2-adrenergic agonist clonidine. The cerebral ischemia rat model was made by right middle cerebral artery occlusion for 2 h and reperfu- sion for 4 h. The Sprague Dawley rats were randomly divided into the sham-operative group, the cerebral ischemia model group, the clonidine group, the yohimbine ＋ clonidine group and the yohimbine group. The results shown that neurological deficit scores of rats pretreated with clonidine before the ischemia were better than the sham-opera- tive group. Clonidine group had significantly reduced brain infarct volumes. Clonidine decreased the expression of phospho-NMDAR2B and increased the expression of phospho-NMDAR1 and NMDAR2A. Therefore, clonidine sig- nificantly alleviated cerebral ischemia / reperfusion injury. The mechanism may be related to the regulation of phos- pho-NMDAR2B, phospho-NMDAR1 and NMDAR2A during cerebral ischemia/reperfusion.

关 键 词：缺血/再灌注损伤 脑缺血模型 可乐定 Α2-肾上腺素能受体激动剂 调节 减轻 右侧大脑中动脉阻塞 神经功能缺损评分 

分 类 号：R541[医药卫生—心血管疾病] R743.302[医药卫生—内科学]