早孕期血清25-OH-VitD与子宫动脉PI联合检测对早发型重度子痫前期预测价值的研究  

The Value of Prediction Study on Early-onset Severe Preeclampsia by Maternal Serum 25-OH-VitD Jointed With Uterine Artery Doppler Pulsatility Index in First-trimester Pregnancy

作　　者：尹昕[1] 侯延庆[1] 

机构地区：[1]广东医学院附属南山医院,深圳518052

出　　处：《中国继续医学教育》2015年第28期35-37,共3页China Continuing Medical Education

基　　金：深圳市南山区卫生科技资助项目(南科研卫2012024)

摘　　要：目的研究早孕期血清25-OH-Vit D水平与子宫动脉PI联合检测对早发型重度子痫前期（EOSP）的预测价值。方法选择2013年1月~2015年1月在我院门诊早孕期建卡的初次单胎妊娠无合并症的妇女5 000例作为研究对象,孕周为8~13周＋6天,用化学发光法进行血清维生素D（25-OH-Vit D）水平检测,并记录入选者在孕11~13周＋6天测NT时行双侧子宫动脉PI值的测定。共有1 748例孕妇完成研究,规律产检并在我院分娩。实验分组：A组维生素D水平正常＋PI〈2.4;B组维生素D水平缺乏＋PI〈2.4;C组维生素D水平正常＋PI〉2.4;D组;维生素D水平缺乏＋PI〉2.4;比较4组EOSP发病率。结果 EOSP患者早孕期血清维生素D缺乏者为96%,低于正常孕妇,而PI值高于正常组,P〈0.05。EOSP发病率D组最高,A组最低,均与其它三组差异明显,P〈0.05。B与C组无明显差异。结论早孕期维生素D缺乏可能是EOSP发病的独立危险因素。早孕期血清维生素D与子宫动脉PI联合检测对EOSP发病有较好的预测价值。Objective To study value of prediction study on early- onset severe preeclampsia （EOSP）by maternal serum 25-OH-VitD jointed with uterine artery Doppler pulsatility index （UtAD-PI） in First-trimester pregnancy. Methods 5 000 early singleton pregnancy women with gestational age 8-13weeks＋6days and without any complications in our hospital outpatient department from January 2013 to January 2015 were involved. The levels of serum 25-OH-VitD were measured by chemiluminescence method. And all pregnant women＇s UtAD-PI were measured when nuchal translucency （NT） measured. Only 1 748 women went through the whole study. They were divided into 4 groups, Group A included patients with serum normal Vitamin D and PI〈2.4,Group B with serum .Vitamin D deficiency and PI〈2.4, Group C with serum normal Vitamin D and PI〉2.4, Group D with serum Vitamin D deficiency and PI〉2.4. The occurrence rate was calculated in different groups. Results EOSP Patients with Vitamin D deficiency were 96%, The levels of serum 25-OH-VitD was significantly lower than in normal control group, And the value of PI was significantly higher in EOSP than normal group, P〈0.05. The occurrence rate of EOSP in group D was highest and in group A is lowest, the difference had statistically significance, P〈0.05. But group B and C had no significantly difference in occurrence rate of EOSP. Conclusion Vitamin D deficiency in First-trimester is probably a Independent risk factor for EOSP patients. Serum 25-OH-VitDmeasuredjointed with UtAD-PI in First-trimester pregnancy could have better prediction value for EOSP.

关 键 词：早发型重度子痫前期 血清25-OH-VitD 子宫动脉PI值 

分 类 号：R714[医药卫生—妇产科学]