卵巢癌新辅助化疗监测过程中血清CA125联合经阴道彩色多普勒超声的应用价值  

Application value of serum CA125 combined with transvaginal color Doppler ultrasonography in monitoring adjuvant chemotherapy of ovarian cancer

作　　者：刘恩令[1] 周玉秀[2] 李向佩 王庆文[3] 王立群[1] 张艳梅[1] 王颖[1] 李君[1] 

机构地区：[1]河北医科大学附属唐山市工人医院妇产科,河北省唐山市063000 [2]河北医科大学附属唐山市工人医院免疫科,河北省唐山市063000 [3]河北医科大学附属唐山市工人医院超声科,河北省唐山市063000

出　　处：《临床超声医学杂志》2015年第10期680-682,共3页Journal of Clinical Ultrasound in Medicine

摘　　要：目的探讨卵巢癌新辅助化疗疗效监测过程中血清CA125联合经阴道彩色多普勒超声(TV-CDFI)的应用价值。方法 134例卵巢癌患者行TV-CDFI检查及血清CA125水平监测后采用新辅助化疗,治疗后复查TV-CDFI和CA125水平,与术后病理结果对比。结果新辅助化疗后TV-CDFI检查显示残余癌灶径线明显缩小,阻力指数增大,最大血流速度减小,血流丰富程度降低(P<0.05)。单独使用血清CA125检测卵巢癌原发灶化疗的特异性为66.7%,敏感性为62.1%,准确率为72.4%;单独使用TV-CDFI检测的特异性为86.7%,敏感性为87.1%,准确率为85.1%;血清CA125联合TV-CDFI检测的特异性为66.7%,敏感性为97.4%,准确率为85.8%,较单独采用两种检测方法均有提高,差异有统计学意义(P<0.05)。结论血清CA125联合TV-CDFI能进一步提高新辅助化疗的效果监测,可指导临床治疗。Objective To investigate the value of serum CA125 combined with transvaginal color Doppler ultrasonography flow imaging（TV-CDFI） in monitoring adjuvant chemotherapy in patients with ovarian cancer.Methods One hundred and thirty-four patients with ovarian cancer underwent serum CA125 and TV-CDFI testing pre- and post-new adjuvant chemotherapy.The results were compared with those of surgical pathology.Results TV-CDFI showed the size of residual tumor,the maximum velocity and blood supply were decreased,the resistance index（RI） was increased after adjuvant chemotherapy.The specificity,sensitivity and accuracy of serum CA125 level,TV-CDFI and combination method in evaluating the adjuvant chemotherapy were 66.7%,62.1%,72.4%,86.7%,87.1%,85.1%,66.7%,97.4%,85.8%,respectively,there was significant difference（P〈0.05）.Conclusion Serum CA125 combined with TV-CDFI is able to accurately evaluate treatment response to adjuvant chemotherapy and guide the clinical therapy.

关 键 词：卵巢癌 新辅助化疗 超声检查 经阴道 免疫放射分析法 

分 类 号：R445.1[医药卫生—影像医学与核医学]