布地奈德福莫特罗对支气管扩张症合并支气管哮喘患者肺功能及生活质量的影响  

Effect of budesonide formoterol on lung function and quality of life in patients with bronchiectasis complicated with bronchial asthma

作　　者：石明[1] 唐友勇[1] 杨中卫[1] 李威[1] 王正艳[1] 袁美春[2] 

机构地区：[1]湖北医药学院附属东风医院呼吸内科,湖北省十堰市442008 [2]湖北医药学院基础医学院

出　　处：《中国医药》2015年第11期1593-1595,共3页China Medicine

基　　金：湖北省教育厅科学技术研究项目（Q20132103）

摘　　要：目的 探讨布地奈德福莫特罗对支气管扩张症合并支气管哮喘患者肺功能及生活质量的影响.方法 选择2012年6月至2015年1月于湖北医药学院附属东风医院就诊的支气管扩张症合并支气管哮喘患者98例,根据随机数字表法分为观察组和对照组,各49例.对照组给予布地奈德吸入治疗,观察组给予布地奈德福莫特罗吸入治疗,2组均治疗15 d.比较2组患者治疗前后肺功能、炎性因子水平、生活质量评分以及不良反应发生情况.结果 治疗15 d后,观察组第1秒用力呼气容积和用力肺活量明显高于治疗前和对照组同时点[（2.3 ±0.5）L比（1.9±0.5）、（2.1±0.7）L,（3.5±0.9）L比（3.1±0.9）、（3.2±0.5）L],白细胞介素4、肿瘤坏死因子α、生活质量评分明显低于治疗前和对照组同时点[（5.4±2.1） ng/L比（27.3±2.4）、（9.1±1.9）ng/L,（20±14） ng/L比（124±14）、（50±14） ng/L,（36±5）分比（49±5）、（45±5）分],差异均有统计学意义（均P ＜0.05）.观察组治疗过程中出现声音嘶哑2例、口干1例、心慌1例;对照组出现声音嘶哑1例、口干2例,2组对症处理后均好转,2组不良反应发生率比较[8.2％（4/49）比6.1％ （3/49）],差异无统计学意义（P＞0.05）.结论 布地奈德福莫特罗能明显改善支气管扩张症合并支气管哮喘患者的气道炎症、肺部功能和生活质量,安全性、可靠性较好。Objective To explore the effect of budesonide formoterol on lung function and quality of life in patients with bronchiectasis complicated with bronchial asthma.Methods Totally 98 patients with bronchiectasis complicated with bronchial asthma from June 2012 to January 2015 were randomly divided into observation group （49 cases） given inhalation of budesonide formoterol, and control group （49 cases） given inhalation of budesonide;the treatment was lasted for 15 d.The lung function, levels of inflammatory cytokines, score of life quality and adverse reactions before and after treatment were compared between the two groups.Results After treatment, the forced expiratory volume in one second and forced vital capacity in observation group were obviously higher than those before treatment and those in control group at the same time point [（2.3 ± 0.5） L vs （1.9 ± 0.5）, （2.1 ±0.7） L, （3.5 ±0.9） L vs （3.1 ±0.9）, （3.2 ±0.5） L].The serum interleukin-4, tumor necrosis factor-a, score of life quality in observation group after treatment were significantly lower than those before treatment and those in control group at the same time points [（5.4 ± 2.1） ng/L vs （27.3 ± 2.4）, （9.1 ± 1.9） ng/L, （20±14） ng/Lvs （124±14）, （50±14） ng/L;（36±5） scoresvs （49±5）, （45±5） scores] （P 〈 0.05）.During treatment, 2 patients had hoarse voice, 1 patient had dry mouth and 1 patients had palpitation in observation group;1 patients had hoarse voice, 2 patient had dry mouth in control group;all the patients recovered after symptomatic treatment;the incidence of adverse reactions had no significant difference between observation group and control group [8.2% （4/49） vs 6.1% （3/49）] （P 〉0.05）.Conclusion Budesonide formoterol can obviously improve the lung function, airway inflammation and life quality in bronchiectasis patients complicated with bronchial asthma.

关 键 词：支气管扩张症 支气管哮喘 布地奈德福莫特罗 肺功能 生活质量 

分 类 号：R562.2[医药卫生—呼吸系统]