医用生物蛋白胶在乳腺癌手术中应用的Meta分析  

Fibrin glue application in breast surgery: a Meta-analysis

作　　者：付雷[1] 邢程程[2] 

机构地区：[1]中国医科大学附属盛京医院,辽宁省沈阳市110004 [2]中国医科大学附属第一医院,辽宁省沈阳市110001

出　　处：《中国组织工程研究》2015年第38期6228-6232,共5页Chinese Journal of Tissue Engineering Research

摘　　要：背景:医用生物蛋白胶近年来在乳腺癌手术中得到广泛的应用,但多数文献纳入的病例数少,应用效果存在一定差异。目的:系统评价医用生物蛋白胶在乳腺癌手术中应用的效果。方法:计算机检索中国期刊网全文数据库(CNKI)、维普数据库、万方数据库2002年3月至2014年3月公开发表的关于在乳腺癌手术中医用生物蛋白胶应用的随机对照临床试验文献,对纳入的研究采用Rev Man 5.2统计学软件进行Meta分析。结果与结论:Meta分析共纳入11项研究,合计1 043例患者。结果显示,应用医用生物蛋白胶的实验组术后第1天引流量[WMD=-85.62,95%CI(-128.86,-42.39),P=0.000 1]及术后总引流管引流量[WMD=-167.27,95%CI(-210.05,-124.49),P<0.000 01]都显著少于对照组,实验组术后皮下积液率[OR=0.30,95%CI(0.21,0.44),P<0.000 01]优于对照组,两组比较差异有显著性意义。提示在乳腺癌根治手术采用医用生物蛋白胶后可显著减少引流液,乳腺癌术后皮下积液的发生率明显降低。BACKGROUND： Fibrin glue has been widely used in breast surgery, but due to the limitation of cases, there are some differences in clinical effects. OBJECTIVE： To systemically review the clinical effect of fibrin glue in breast surgery. METHODS： We searched China Journal Full-text Database（CNKI）, VIP database, Wanfang Database for clinical randomized controlled trials related to fibrin glue used in breast surgery published from March 2002 to March 2014. A Meta-analysis was done in included studies using Rev Man 5.2 statistical software. RESULTS AND CONCLUSION： A total of 11 studies, with 1 043 cases, were enrolled for the Meta-analysis. Meta-analysis showed that the postoperative 1-day drainage amount and total drainage amount were significantly lower in the fibrin glue group than the control group [WMD=-85.62, 95%CI（-128.86,-42.39）, P=0.000 1; WMD=-167.27, 95%CI（-210.05,-124.49）, P〈0.000 01]. In addition, the fibrin glue group was superior to the control group in the postoperative seroma rate [OR=0.30, 95%CI（0.21, 0.44）, P〈0.000 01]. Application of fibrin glue in breast cancer surgery can significantly reduce postoperative drainage and seroma rate.

关 键 词：乳腺肿瘤 纤维蛋白组织粘着剂 引流术 生物材料 材料相容性 医用生物蛋白胶 乳腺癌手术 META分析 

分 类 号：R318[医药卫生—生物医学工程]