正十二烷基酚的合成及条件优化  

Synthesis of dodecyl phenol and process conditions optimization

作　　者：李博洋[1] 丁伟[1] 武松[1] 张瀚文[1] 宋成龙[1] 

机构地区：[1]东北石油大学化学化工学院,黑龙江大庆163318

出　　处：《化工科技》2015年第5期1-5,共5页Science & Technology in Chemical Industry

基　　金：十二五国家重大专项项目(2011ZX05011-004);黑龙江省自然科学基金重点项目(ZJG0507)

摘　　要：以正月桂酰氯和苯酚为原料,甲苯为溶剂,无水三氯化铝为催化剂,通过Fries重排反应合成对羟基苯基十一烷基酮,该烷基酮经过黄鸣龙还原反应最终生成正十二烷基酚。通过正交与单因素实验探讨了合成对羟基苯基十一烷基酮的优化条件,并简单描述了烷基酚合成中单组分因素对还原反应的影响,最终确定了对羟基苯基十一烷基酮最佳工艺条件为:反应温度为100℃,反应时间为4h,n(苯酚)∶n(正月桂酰氯)∶n(甲苯)∶n(无水三氯化铝)=1∶1∶1.1∶1.2,产率可达79.8%。The experiment was based on using auroyl chloride and phenol as raw materials,toluene as solvent and anhydrous aluminium chloride as catalyst,p-hydroxy phenyl undecyl ketone was synthesized by Fries rearrangement reaction.The alkyl ketone eventually was generated dodecyl phenol by Wolf-Kishner-Huang reduction.In the whole process of our research,intermediate for p-hydroxy phenyl undecyl ketone content plays an important role in the Wolff-Kishner-Huang reduction.The content will influences the production rate of dodecyl phenol.Therefore we discussed optimum conditions of synthesis of p-hydroxy phenyl undecyl ketone.by orthogonal and single factor experiment,and simply described the effects of single component factors on reduction reaction of synthesis of alkyl phenol.We also describe the effect of various factors in the reduction reaction.Ultimately the optimum process conditions of p-hydroxy phenyl undecyl ketone were determined as follows：reaction temperature is100℃,reaction time is 4h,n（phenol）∶n（positive lauroyl chloride）∶n（toluene）∶n（anhydrous aluminium trichloride）=1∶1∶1.1∶1.2,the yield can reach 79.8%.

关 键 词：烷基酮 烷基酚 黄鸣龙还原反应 优化设计 

分 类 号：TQ423.12[化学工程]