利用超临界CO_2制备聚合物载药微粒的研究进展  

Research in preparation of polymer drug-loaded particles by supercritical CO_2

作　　者：刘楠[1,2] 王卫京[1,2] 赵启成[1,2] 王景昌[1,2] 宫蕾[1,2] 詹世平[1,2] 

机构地区：[1]大连大学环境与化学工程学院,大连116622 [2]辽宁省化工环保工程技术研究中心,大连116622

出　　处：《化工新型材料》2015年第10期212-214,217,共4页New Chemical Materials

基　　金：国家自然科学基金项目(21176032)

摘　　要：近年来,各种缓、控释给药系统成为医药行业的研究热点,如何制备安全、便捷、高效、副作用小的载药微粒引起人们的广泛关注。超临界流体技术因其绿色、环保等特点,在制备载药微粒领域起着越来越重要的作用。在载药微粒的制备过程中,根据超临界CO2所起的作用不同,超临界流体技术可分为以下3类:超临界CO2作溶剂、超临界CO2作溶质和超临界CO2作抗溶剂。本研究分别介绍相应条件下的几种载药微粒的制备方法,如超临界流体快速膨胀法、超临界流体浸渍法、气体饱和溶液法、超临界流体辅助雾化过程及超临界抗溶剂法。介绍了这些方法的研究现状,并对其进行了分析和比较。最后对超临界流体技术在制备载药微粒方面的前景进行了展望。In recent years,a variety of sustained and controlled release drug delivery systems become research focus,how to prepare drug particles of safety,convenience,efficiency,less side effect caused widespread concern.Supercritical fluid technology because of its green,environmentally friendly features,makes an increasingly important role in the preparation of drug-loaded particles field.During the preparation of drug-loaded particles,according to the different role of supercritical CO2（ScCO2）,supercritical fluid technology can be divided into the following three categories：ScCO2as solvent,ScCO2 as solute and ScCO2 as anti-solvent.The several methods of prepared drug-loaded particles under the corresponding conditions were reviewed,such as：rapid expansion from saturated solutions（RESS）,supercritical solvent impregnation（SSI）,particles from gas saturated solutions（PGSS）,supercritical fluid-Assisted atomization（SAA）and supercritical anti-solvent process（SAS）.The research progress of these methods was summarized,and analyzed and compared.Finally,the prospect for the preparation of drug-loaded particles by supercritical fluid technology was discussed.

关 键 词：超临界CO2 载药微粒 快速膨胀法 抗溶剂技术 

分 类 号：TQ460.1[化学工程—制药化工] O631[理学—高分子化学]