言语工作记忆负荷的事件相关电位时空模式分析  

Effects of verbal working memory load: spatiotemporal analysis of event-related potentials

作　　者：胡玮冰 周曙[1] 王优[2] 黄冬玲[1] 曹园[1] 

机构地区：[1]南方医科大学南方医院神经内科,广东广州510515 [2]南方医科大学公共卫生与热带医学学院心理学系,广东广州510515

出　　处：《南方医科大学学报》2015年第9期1268-1271,共4页Journal of Southern Medical University

基　　金：国家自然科学基金(81200962)~~

摘　　要：目的运用事件相关电位(ERP)探索言语工作记忆负荷关联的神经网络演化。方法 21名被试者按键完成言语材料的延迟匹配样本任务,工作记忆负荷分别是3和5个字母,分析工作记忆容量(WMC)及19通道ERP统计参数映像(SPM)的时空模式。结果高负荷(3.30±0.76)vs低负荷(2.48±0.30),WMC差异有统计学意义(t=5.950,P=0.000)。SPM显示:编码期的负荷效应相继出现在右腹侧、背侧注意网络和左额颞顶语言区;维持期的负荷效应出现在右腹侧注意网络,先后与背侧注意网络和左额颞区相伴。结论在言语工作记忆负荷超出其有限容量时,右腹侧注意网络可能参与防止项目之间混淆和言语长时记忆的激活。Objective To explore the influence of verbal working memory load on associative neural networks. Methods Twentyone subjects were required to complete a verbal delayed matching-to-sample task under the condition of low（3 items） or high（5 items） working memory load（WML）. The 19- channels event- related potentials（ERP） were analyzed with statistical parametric mapping. Results A significant difference in working memory capacity（WMC） was found between low WML and high WML groups [2.48 ± 0.30 vs 3.30 ± 0.76; t（20） =5.950, P=0.000]. Statistical parametric mapping revealed that during the encoding stage, the effects of WML appeared in succession in the right ventral attention network（r VAN）, the dorsal attention network, and the language areas in the left hemisprere. During the maintenance stage, the effects WML occured in the r VAN acompanied by either DAN or left frontal-temporal regions. Conclusions When the WML is beyond the WMC, the r VAN may participate in the prevention of interference among items and in the activation of long-term memory.

关 键 词：工作记忆 事件相关电位 统计参数映像 

分 类 号：R338[医药卫生—人体生理学]