五指山小型猪肝脏的三维数字化建模  

Construction of a three-dimensional digital model of the liver of Wuzhishan mini-pig

作　　者：张立力[1] 肖菊姣 许广威[2] 孔祥雪[2] 付茂庆[2] 王张林 李鉴轶[2] 

机构地区：[1]南方医科大学护理学院,广东广州510515 [2]南方医科大学人体解剖学教研室//广东省医学生物力学重点实验室,广东广州510515

出　　处：《南方医科大学学报》2015年第9期1362-1365,共4页Journal of Southern Medical University

基　　金：广东省自然科学基金(S2011010004179);广州市科研条件建设项目(穗科信字[2011]233-39号)

摘　　要：目的建立五指山小型猪肝脏的三维数字化模型,并进行肝脏相关术式的虚拟设计,为肝切除术培训提供参考模型。方法用过氯乙烯乙酸乙酯材料混合氧化铅灌注胆总管、肝总动脉,牙托材料混合氧化铅灌注肝静脉、门静脉。对灌注后的肝脏标本进行CT扫描,所获得的数据用mimics软件进行三维重建,并设计肝切除术的断层图像。用浓盐酸腐蚀灌注标本,制作小型猪肝内管道结构铸型标本。结果铸型标本轮廓较饱满,管道末梢细密,可显示门静脉、肝静脉的5~6级分支,肝动脉、胆管的3~4级分支。三维数字化模型立体感强,可清晰显示肝静脉、门静脉的3~4级分支,肝动脉、胆管的2~3级分支。三维数字化模型显示的分级数比铸型标本少,但能显示的管道结构分布走行情况与铸型标本相同。虚拟切割肝组织,可清晰显示肝断面的管道结构与肝脏软组织的空间位置关系。结论三维数字化模型可清晰立体地显示肝脏内部管道结构的分布走行,虚拟术式设计可提供大致的肝脏断面管道结构分布情况,为腹腔镜肝切除术培训提供数字化参考模型。Objective To construct a three- dimensional（3D） liver model of Wuzhishan mini- pig for virtual liver surgeries.Methods The biliary tree and hepatic arteries of Wuzhishan mini-pig were perfused with perchloroethylene and ethyl acetate along mixed with lead oxide, and the hepatic vein and portal vein were perfused with a mixture of dental base acrylic resin and lead oxide. The sectional images were acquired using a 64- slice spiral CT, and the 3D models of the portal vein, hepatic vein, biliary tree, hepatic arteries, and liver parenchyma were reconstructed using Mimics software; the resection image of the liver was also designed. The intrahepatic vascular cast was prepared by corroding the soft tissue with hydrochloric acid.Results and Conclusion The intrahepatic vascular cast obtained fully retained the vascular architecture and displayed the fifth- and sixth-level branches of the hepatic vein and portal vein and the third- and fourth-level branches of the artery and bile duct. The 3D model of liver allowed stereoscopic and accurate display of the third- and fourth- level branches of the hepatic vein and portal vein and the second- and third- level branches of the artery and bile duct. The 3D model showed fewer branches but represented the structural distribution identical to the cast. The 3D model could clearly display the spatial relationship between the vasculature and the soft tissue in virtual resection of the liver tissues, and thus provides a useful model for training of laparoscopic liver resection.

关 键 词：三维重建 培训 铸型标本 腹腔镜肝切除术 

分 类 号：R657.3[医药卫生—外科学]