经皮冠状动脉介入联合替罗非班治疗急性ST段抬高型心肌梗死对患者心功能的影响  

Influence of PCI combined with Tirofiban therapy on acute STEMI patients' cardiac function indicators

作　　者：杨劲松[1] 刘玉梅[1] 杨海松[2] 徐妍[1] 

机构地区：[1]吉林医药学院附属医院心血管内科,吉林吉林132013 [2]吉林医药学院附属医院普通外科,吉林吉林132013

出　　处：《中国现代医学杂志》2015年第28期74-77,共4页China Journal of Modern Medicine

摘　　要：目的分析PCI联合替罗非班治疗急性ST段抬高型心肌梗死对患者心功能的影响。方法 2013年7月-2014年7月,选择接受PCI联合替罗非班治疗的急性ST段抬高型心肌梗死患者47例作为观察组,另取同期在该院接受单纯PCI治疗的急性ST段抬高型心肌梗死患者45例作为对照组,测定两组患者的术后再灌注指标、心脏功能指标水平,记录治疗1个月内心血管事件发生率。结果观察组患者接受治疗后2 h,TIMI 3级血流比例、ST段回落>50%比例均高于对照组,CK-MB峰值及峰值时间小于对照组患者(P<0.05);PCI术后6个月LVEF值大于对照组,LVESD、LVEDD值小于对照组患者(P<0.05);治疗1个月内心血管事件发生率低于对照组患者(P<0.05)。结论 PCI联合替罗非班可以有效恢复梗死冠脉灌注,优化心功能的同时降低心血管事件发生率。[ Objective ] To analyze the influence of PCI combined with Tirofiban therapy on acute STEMI patient＇s cardiac function indicators. [Methods] 47 cases of acute STEMI patients between July 2013 to July 2014 who received PCI combined with Tirofiban therapy as observation group, in the same time, 45 cases of acute STEMI patients received PCI treatment alone as control group, measured reperfusion index, cardiac function index level, recorded cardiovascular event rate. [ Results ] Observation group patients receiving TMI3 level perfusion ratio, ST segment resolution 〉 50% ratio after treatment were higher, CK-MB peak and peak time were shorter than control group patients （P 〈 0.05）; 6 month after PCI treatment, observation group patient＇s LVEF values was larger than control group, LVESD, LVEDD values were smaller than control group patients （P 〈 0.05）; cardiovascular event rate in one month after treatment was lower than control group patients （P 〈 0.05）. [ Conclusion] PCI combines with Tirofiban can effectively restore coronary perfusion infarction, optimize cardiac function while reduces incidence of cardiovascular events.

关 键 词：ST段抬高型心肌梗死 PCI 替罗非班 心功能 

分 类 号：R541.4[医药卫生—心血管疾病]