垂体生长激素腺瘤合并阻塞性睡眠呼吸暂停低通气综合征及睡眠低氧的危险因素  

Risk factors of obstructive sleep apnea hypopnea syndrome and sleep hypopnea in patients with growth hormone-secreting pituitary adenoma

作　　者：郭晓鹏[1] 高路[1] 李一琳[1] 张硕[1] 姚勇[1] 连伟[1] 王任直[1] 幸兵[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院神经外科,北京100730

出　　处：《南方医科大学学报》2015年第10期1501-1504,1518,共5页Journal of Southern Medical University

摘　　要：目的探讨垂体生长激素(GH)腺瘤合并阻塞性睡眠呼吸暂停低通气综合征(OSAHS)及睡眠低氧(SH)的危险因素。方法严格按照入组及排除标准选取85例垂体GH腺瘤患者,所有患者入院后均行睡眠呼吸监测。收集患者的临床资料、化验结果、影像资料进行对比分析,并采用二元logistic回归分析相关危险因素。结果该组垂体生长激素腺瘤患者合并OSAHS的发生率为62.4%(53/85),合并SH的发生率为75.3%(64/85)。进行回归分析得出年龄(OR=1.107)及BMI(OR=1.166)为OSAHS的危险因素,BMI(OR=1.334)为SH的危险因素。结论高龄及BMI增加是垂体GH腺瘤患者合并OSAHS及SH的独立危险因素。术前常规行睡眠呼吸监测,早期识别患者并指导患者保持健康体重,是降低患者呼吸系统相关死亡率的有效方法。Objective To investigate the risk factors contributing to the development of obstructive sleep apnea hypopnea syndrome（OSAHS） and sleep hypopnea（SH） in patients with growth hormone-secreting pituitary adenoma（GHPA）.Methods A total of 85 patients with GHPA recruited strictly according to the inclusion and exclusion criteria underwent sleep monitoring overnight. Clinical manifestations, laboratory data and magnet resonance images were collected for analysis of the risk factors of GHPA and SH using binary logistic regression analysis. Results The prevalence rate of OSAHS was 62.4%（53/85）, and that of SH was 75.3%（64/85） in the recruited patients with GHPA. Regression analysis showed that age（OR=1.107）and BMI（OR=1.166） were the risk factors for OSAHS, and BMI（OR=1.334） was the risk factor of SH. Conclusions Ageing and an increased BMI are independent risk factors for OSAHS and SH in patients with GHPA. Preoperative sleep monitoring should be routinely conducted to ensure early diagnosis of OSAHS and SH, and patients with GHPA should be advised to control their body weight to lower the mortality associated with the respiratory system.

关 键 词：垂体生长激素腺瘤 肢端肥大症 阻塞性睡眠呼吸暂停低通气综合征 睡眠低氧 

分 类 号：R766[医药卫生—耳鼻咽喉科] R736.4[医药卫生—临床医学]