靶向免疫系统的递药系统研究进展  

Research advances in drug delivery system targeting immune system

作　　者：贺威[1] 齐海霞[1] 董磊[1] 张峻峰[1] 

机构地区：[1]南京大学生命科学学院医药生物技术国家重点实验室,南京210046

出　　处：《中国药科大学学报》2015年第5期513-520,共8页Journal of China Pharmaceutical University

基　　金：国家杰出青年科学基金资助项目(No.81025019);国家高技术研究发展计划(863计划)资助项目(No.2014AA020707);国家自然科学基金资助项目(No.51173076)~~

摘　　要：靶向免疫系统的递药系统在治疗炎症性疾病中发挥着重要作用。靶向免疫系统的递药系统可靶向免疫细胞或免疫器官,分为由配体-受体和抗原-抗体介导的主动靶向以及pH、颗粒介导的被动靶向。本文针对上述分类,综述了近年来靶向免疫系统的递药系统的新进展,为设计安全有效的靶向免疫细胞或免疫器官的递药系统、以及对炎症性疾病的高效安全治疗提供理论参考。Drug delivery system targeting immune system plays an important role in the treatment of inflammatory diseases.Drug delivery system targeting immune system could target immune cells or immune organs.It could be divided into active targeting mediated by the interaction of ligand-receptor or antigen-antibody and passive targe-ting mediated by pH;particles and so on.This review summarizes new progress for drug delivery system targeting immune system;which provides a theoretical reference for designing the safe and effective drug delivery system and providing efficient and safe treatment for inflammatory diseases.

关 键 词：靶向药物输送系统 免疫系统 免疫细胞 免疫器官 主动靶向 被动靶向 

分 类 号：R943[医药卫生—药剂学]