中药有效成分抑制氧化应激诱导的神经细胞凋亡机制研究进展  

Research advances in the mechanisms of active components in Chinese materia medica against oxidative stress-induced neuronal apoptosis

作　　者：申凯[1] 寇俊萍[1] 余伯阳[1] 

机构地区：[1]江苏省中药评价与转化重点实验室,中国药科大学中药复方研究室,南京211198

出　　处：《中国药科大学学报》2015年第5期532-540,共9页Journal of China Pharmaceutical University

基　　金：国家自然科学基金资助项目(No.81274004)~~

摘　　要：氧化应激诱导的神经细胞凋亡,在神经退行性疾病的发生及发展过程中发挥重要作用,其调控途径主要包括NF-κB通路、p53通路、MAPK通路、PI3K/Akt通路、Nrf2通路等信号通路。大量文献报道,中药有效成分具有显著抑制氧化应激诱导的神经细胞凋亡的生物活性。本文综述近5年来中药有效成分抑制氧化应激诱导的神经细胞凋亡的相关机制研究进展,以期为阐释中药有效成分防治神经退行性疾病的作用机制,更有效地防治神经退行性疾病提供参考依据和线索。Oxidative stress-induced neuronal apoptosis plays a vital role in the development of neurodegenerative disorders;while at present its regulation pathways mainly include the NF-κB pathway;p53 pathway;MAPK path-way;PI3 K/Akt pathway;Nrf2 pathway;as well as other signaling pathways.Research findings suggest that the active components in Chinese materia medica exert significant biological activities in the treatment of oxidative stress-induced neuronal apoptosis.In the present paper;we review the recent research advances on the relative mechanisms of active components in Chinese materia medica against oxidative stress-induced neuronal apoptosis;so as to provide some references or clues for the clarification of possible mechanisms of active components in Chinese materia medica and the treatment of related neurodegenerative diseases.

关 键 词：中药有效成分 神经细胞 氧化应激 凋亡 神经退行性疾病 

分 类 号：R284[医药卫生—中药学] R965[医药卫生—中医学]