慢性肺心病急性加重期患者动脉血气NT-proBNP与hs-CRP的研究  

Observation of arterial blood gases,NT- pro BNP and h S- CRP levels in patients with acute exacerbation of chronic pulmonary heart disease

作　　者：常湘辉[1] 李秀萍 陈梅[1] 邵萍 黄晓波[1] 许旺[1] 

机构地区：[1]宁夏银川市第一人民医院心内科,宁夏银川750001 [2]宁夏体检复康保健中心,宁夏银川750011

出　　处：《宁夏医学杂志》2015年第10期890-892,共3页Ningxia Medical Journal

摘　　要：目的观察慢性肺心病急性加重期患者治疗前后动脉血气分析情况,血浆N-端脑钠肽前体(NTpro BNP)和超敏C反应蛋白(hs-CRP)的变化,探讨其与肺心病病情严重程度及疗效的相关性。方法 60例慢性肺心病急性加重期患者给予2周的综合治疗,治疗前后检测动脉血气分析,血浆NT-pro BNP和h S-CRP。结果慢性肺心病急性加重期患者动脉血气分析,血浆NT-pro BNP和hs-CRP存在明显异常,与病情的严重程度有相关性;治疗2周后,动脉血Pa O2(氧分压)、Pa CO2(二氧化碳分压)、血浆NT-pro BNP、hs-CRP与治疗前比较明显改善,差异有统计学意义(P<0.05);且NT-pro BNP水平随肺动脉高压严重程度而升高,NT-pro BNP水平在轻、中、重度肺动脉高压组中差异有统计学意义(P<0.05)。结论血浆NT-pro BNP、hs-CRP可作为判定肺心病急性加重期患者病情严重程度及疗效的指标。Objective To observe the variation of arterial blood gases,NT- pro BNP and hs- CRP levels in patients with acute exacerbation of chronic pulmonary heart disease or before and after medication for assessing the conditions and therapeutic effects.Methods Patients with acute exacerbation of chronic corpulmonale（ n = 60） and underwent comprehensive therapy for consecutive two weeks. The arterial blood gas（ Pa O2 and Pa CO2） analysis was performed,and the concentration of plasma NT- pro BNP and plasma hs-CRP were determined and compared before and after treatment. Results Significant abnormal levels of arterial Pa O2 and Pa CO2,plasma NT- pro BNP and plasma hs- CRP were seen in patients with acute exacerbation of chronic pulmonary heart disease,suggesting that these indicators were associated with severity of the conditions. After two weeks of medication,the previous indicators were improved significantly,which had statistical difference（ P〈0. 05）. The level of NT- pro BNP increased with severity of,there were significant differences in mild,moderate and severe pulmonary hypertension. Conclusion The levels of plasma NT- pro BNP and hs- CRP may serve as indicators for estimation of the severity of acute exacerbation of chronic pulmonary disease and its curative outcomes.

关 键 词：肺心病 N-端脑钠肽前体 超敏C反应蛋白 血气分析 

分 类 号：R541.5[医药卫生—心血管疾病]