医院感染产β-内酰胺酶金黄色葡萄球菌的耐药分析  

Drug Resistance Analysis of Staphylococcus Aureus Producing β-Lactamase in Hospital Infection

作　　者：桂红[1] 丁军颖[2,3] 高翔[1] 古颖[1] 荣蓉[1] 洪燕英[4] 刘清泉[2,3] 

机构地区：[1]首都医科大学附属北京中医医院检验科,北京100010 [2]首都医科大学附属北京中医医院 [3]北京市中医研究所中医感染性疾病基础研究北京市重点实验室,北京100010 [4]北京首都医科大学附属北京中医医院检验科,北京100010

出　　处：《解放军医药杂志》2015年第10期79-81,共3页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：国家自然科学基金项目(81373813);国家"重大新药创制"科技重大专项(2013ZX09102026)

摘　　要：目的分析2014年首都医科大学附属北京中医医院产β-内酰胺酶金黄色葡萄球菌的分布特点及耐药性。方法收集送检标本15 620例,对产β-内酰胺酶金黄色葡萄球菌进行分离,观察其临床分布特征及耐药性。结果共分离非重复病原菌5075株,其中金黄色葡萄球菌526株(10.4%),包括产β-内酰胺酶金黄色葡萄球菌301株(57.2%),其来源主要为创口分泌液和痰液,分布科室主要有重症监护病房、皮肤科和疮疡外科,对青霉素、红霉素、环丙沙星和苯唑西林等耐药率较高,对呋喃妥因、利奈唑胺和万古霉素的耐药率均为0;多引起呼吸机相关感染、下呼吸道感染和皮肤化脓性感染等。结论产β-内酰胺酶金黄色葡萄球菌分布广泛,其对多种抗生素耐药率高,临床应高度重视。Objective To analyze the characteristics of distribution and drug resistance of staphylococcus aureus producing β-lactamase in Beijing TCM Hospital affiliated to the Capital Medical University in 2014. Methods A total of15 620 samples were collected,and the staphylococcus aureus producing β-lactamase were isolated,and then the characteristics of clinical distribution and drug resistance were observed. Results A total of 5075 bacterium strains were isolated,including 526 strains（ 10. 4%） of staphylococcus aureus,301 strains（ 57. 2%） of staphylococcus aureus producingβ-lactamase. The staphylococcus aureus producingβ-lactamase were mainly from wound secretion and sputum,and were mainly distributed in ICU,dermatology department and department of sores ulceration surgery. The staphylococcus aureus producing β- lactamase had a high rate of drug resistance against Penicillin,Erythromycin,Ciprofloxacin and Oxacillin,but had 0% drug resistance rate against Nitrofurantoin,Linezolid and Vancomycin. The staphylococcus aureus producing β-lactamase could probably cause ventilator associated infections,lower respiratory tract infections,purulent skin infections,etc. Conclusion Staphylococcus aureus producing β-lactamase is widely distributed,and has high rates of drug resistance against many antibiotics. So clinicians should pay more attention to it.

关 键 词：金黄色葡萄球菌 Β-内酰胺酶类 耐药基因 交叉感染 

分 类 号：R378.11[医药卫生—病原生物学] R639[医药卫生—基础医学]