莫西沙星静脉滴注联合口服序贯治疗老年社区获得性肺炎临床观察  

Clinical Observation of Moxifloxacin Intravenous Infusion Combined with Oral in Sequential Therapy of Elderly Patients with Community-acquired Pneumonia

作　　者：单毅[1] 

机构地区：[1]海军总医院急诊科,北京100048

出　　处：《解放军医药杂志》2015年第10期88-90,共3页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

摘　　要：目的探讨莫西沙星静脉滴注联合口服序贯治疗老年社区获得性肺炎(CAP)的临床疗效及免疫功能改善情况。方法选择2014年5月—2015年5月收治的老年CAP 70例,随机分为观察组和对照组,每组35例。对照组给予莫西沙星静脉滴注,观察组给予莫西沙星静脉滴注联合口服序贯治疗。观察两组临床疗效、T细胞亚群变化及不良反应发生情况,比较两组治疗方案的成本-效果比。结果两组临床疗效、临床症状和体征消失时间比较差异无统计学意义(P>0.05)。观察组治疗后CD3+、CD4+及CD4+/CD8+水平均较治疗前和对照组升高,CD8+水平均较治疗前和对照组降低(P<0.05)。观察组不良反应发生率和成本-效果比均低于对照组(P<0.05)。结论莫西沙星静脉滴注联合口服序贯治疗CAP可明显改善免疫功能,不良反应发生率低,可减少住院费用。Objective To investigate clinical effect of Moxifloxacin intravenous infusion combined with oral in sequential therapy of elderly patients with community-acquired pneumonia（ CAP） and improvement of immunological function. Methods A total of 70 elderly patients with CAP from May 2014 to May 2015 were randomly divided into observation group（ n = 35） and control group（ n = 35）. The control group was treated with Moxifloxacin intravenous infusion,while the observation group was treated with sequential therapy by Moxifloxacin intravenous infusion combined with oral medication. Clinical effect,changes of T cell subsets and incidence rate of adverse reaction in the two groups were observed,and the ratio of cost and effect in the two groups were compared. Results There were no significant differences between the two groups in clinical effect,the disappearing times of clinical sings and symptoms（ P 0. 05）. The CD3 ＋,CD4 ＋ and CD4 ＋ / CD8 ＋ levels in the observation group after the treatment were significantly higher,while the CD8 ＋ level in the observation group after the treatment was significantly lower than those before the treatment in the observation group and after the treatment in the control group（ P 0. 05）. The incidence rate of adverse reaction and the cost-effectiveness ratio in the observation group were significantly lower than those in the control group（ P 0. 05）. Conclusion Moxifloxacin intravenous infusion combined with oral medication in Sequential therapy of elderly patients with CAP may effectively improve immune function with a low rate of adverse reaction and less cost of hospitalization.

关 键 词：莫西沙星 肺炎 社区获得性感染 免疫功能 费用效益分析 

分 类 号：R563.1[医药卫生—呼吸系统] R978.1[医药卫生—内科学]