不同基因型珠蛋白生成障碍性贫血患儿血清铁代谢指标分析  

Analysis on iron metabolism indicators in children with various genotypes of thalassemia

作　　者：夏威夷[1] 谭蓉[1] 覃西[1] 

机构地区：[1]海南医学院附属医院检验科,海南海口570102

出　　处：《国际检验医学杂志》2015年第20期2947-2949,共3页International Journal of Laboratory Medicine

基　　金：海口市重点科技项目(2013-67)

摘　　要：目的探讨不同基因型珠蛋白生成障碍性贫血(又称地中海贫血,以下简称为地贫)患儿体内铁代谢状况。方法对218例地贫,57例缺铁性贫血(IDA)患儿以及70例健康儿童(对照组)血清铁(SI)、总铁结合力(TIBC)、转铁蛋白(Tf)、血清铁蛋白(SF)进行检测。结果β地贫双重杂合子或纯合子β0组:SI水平明显高于其余各组(P<0.05),而TIBC、Tf水平则明显低于其余各组(P<0.05);α地贫组(静止型α地贫、标准型α地贫):SI、TIBC水平与对照组比较差异无统计学意义(P>0.05),而Tf水平高于对照组(P<0.05);血红蛋白H病组:TIBC、Tf水平与对照组比较差异有统计学意义(P<0.05),SI与对照组比较差异无统计学意义(P>0.05)。结论用于监测地贫患儿铁负荷的指标,SI和TIBC优于Tf;对于SI异常增高和TIBC明显降低的小细胞性贫血患儿,诊断为β0地贫的可能性大。Objective To study the value of iron metabolism indicatorsin thalassemia .Methods 218 cases of thalassemia ,57 ca‐ses of iron deficiency anemia （IDA） children and 70 healthy children（control group） were enrolled in the study ,and serum iron （SI） ,total iron binding capacity（TIBC） ,transferrin（Tf） ,serum ferritin （SF） were detected for them .Results β‐thalassemia double heterozygous（β0 ） or homozygous group ：SI levels were significantly higher than the other groups（P〈0 .05） ,while TIBC ,Tf levels were significantly lower than the other groups（P〈0 .05）;α‐thalassemia group （static α‐thalassemia ,standard α‐thalassemia）：SI , TIBC levels compared with control group showed no significant difference（P〉0 .05） ,but Tf level was higher than control group（P〈0 .05）;hemoglobin H disease group：when TIBC ,Tf levels compared with the control group ,the difference was statistically signif‐icant（P〈0 .05） ,when SI compared with the control group ,the difference was not statistically significant（P〉0 .05） .Conclusion Compared with Tf ,SI and TIBC are better indicators for monitoring iron loading in children with thalassemia .The increased SI level and decreased TIBC level are two indicators for the diagnosis of β0 thalassemia in children with cellule anaemia .

关 键 词：地中海贫血 血清铁 总铁结合力 转铁蛋白 

分 类 号：R725.5[医药卫生—儿科]