老年类风湿性关节炎患者ANA和抗-CCP检测及其与抑郁的相关性  

ANA and anti-CCP detection in elderly patients with rheumatoid arthritis and their relationship with depression

作　　者：裴文意[1] 蒋浩明[1] 袁海燕[1] 侯健[2] 

机构地区：[1]上海市第一人民医院宝山分院干部科,上海200940 [2]上海市第一人民医院宝山分院检验科,上海200940

出　　处：《国际检验医学杂志》2015年第20期2987-2988,2991,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨老年类风湿性关节炎(RA)患者抗核抗体(ANA)、抗环瓜氨酸肽(CCP)抗体(抗-CCP)表达与抑郁的相关性。方法检测58例老年RA患者(RA组)、50例非RA患者(非RA组)及50例健康体检者(对照组)的ANA、抗-CCP,采用抑郁自评量表(SDS)调查RA患者抑郁发生情况,并分析其与ANA、抗-CCP表达的相关性。结果 RA组抗-CCP的阳性率明显高于非RA组和对照组(P<0.05),而ANA阳性率RA组与非RA组比较差异无统计学意义(P>0.05);活动期患者的ANA、抗-CCP阳性率高于稳定期(P<0.05);合并抑郁的患者ANA、抗-CCP的阳性率明显高于无抑郁者(P<0.05);多元线性回归显示,ANA、抗-CCP的阳性均是老年RA患者抑郁的独立影响因素(P<0.05)。结论老年RA患者ANA、抗-CCP表达明显升高且与病情活动性及抑郁情绪相关。Objective To investigate the expression of antinuclear antibodies（ANA） ,anti‐cyclic citrullinated peptide antibody （anti‐CCP） in elderly patients with rheumatoid arthritis（RA） ,and analyze its relation with depression .Methods ANA ,anti‐CCP were detected in 58 elderly RA patients ,50 non‐RA and 50 healthy people .Self‐rating Depression Scale（SDS） was used to assess the incidence of depression .Results The positive rate of anti‐CCP in RA group was significantly higher than that in control group and non‐RA group（P〈0 .05） ,while there was no significantly difference in positive rate of ANA compared between RA group and non‐RA group（P〉0 .05） .The positive rates of anti‐CCP and ANA in active stage were significantly higher than those in stable stage（P〈0 .05） .The positive rates of anti‐CCP and ANA in RA complicated with depression were significantly higher than those in RA without depression（P〈0 .05） .Multiple linear regression analysis showed that positive rates of anti‐CCP and ANA were all in‐dependent influence factors of depression in elderly RA patients（P〈0 .05） .Conclusion Anti‐CCP and ANA in elderly RA patients over express ,and the positive rates are positively related with disease activity and depression .

关 键 词：类风湿性关节炎 抗核抗体 抗环瓜氨酸肽抗体 抑郁 老年人 

分 类 号：R593.22[医药卫生—内科学]