纤维蛋白单体、D-二聚体等凝血指标检测对产科早期DIC诊断的意义  

The Significance of fibrin monomer,D-Dimer and other blood coagulation indicators detection in the early diagnosis of DIC in obstetrics

作　　者：彭和平[1] 陈冬莲 陈晓英 章青英 董宝荣 曾凡鹏 

机构地区：[1]吉安市第三人民医院检验科,江西吉安343000 [2]清远市中医院检验科,广东清远511500 [3]清远市中医院体检中心,广东清远511500 [4]清远市中医院妇产科,广东清远511500 [5]清远市中医院急诊科,广东清远511500 [6]清远市中医院重症急救中心,广东清远511500

出　　处：《国际检验医学杂志》2015年第20期2992-2993,2996,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨纤维蛋白单体(FM)、D-二聚体(D-D)等凝血指标检测在诊断产科早期DIC诊断中的意义。方法对90例健康的体检妇女(对照组)、270例正常妊娠的妇女(早、中、晚孕各90例)、36例产科早期DIC患者(早期DIC组)进行纤维蛋白单体(FM)、D-二聚体(D-D)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)水平的检测。结果早期DIC组FM、D-D水平高于对照组和妊娠组各期(P<0.05);晚孕组PT、APTT比早、中孕组及对照组明显缩短,FIB明显升高,差异均有统计学意义(P<0.05)。结论 PT、APTT、FIB能反映妊娠晚期血液处于高凝状态,但不能诊断产科早期DIC,对于产科早期DIC的诊断,FM、D-D具有重要价值。Objective To investigate the significance of fibrin monomer（FM ） ,D‐Dimer（D‐D） and other blood coagulation indica‐tors detection in the early diagnosis of disseminated intravascular coagulation（DIC） in obstetrics .Methods 90 healthy women with‐out pregnancy（control group） ,270 normal pregnant women including early ,mid‐,late pregnancy（90 cases for each） ,36 early DIC puerperas（early DIC group） were enrolled in the study .FM ,D‐D ,prothrombin time （PT ） ,activated partial coagulation activity （APTT） ,fibrinogen（FIB） levels were detected for those people .Results The levels of D‐D and FM in early DIC group were signif‐icantly higher than those in control group （P〈0 .05） ,and PT ,APTT in late pregnant group were significantly shorter than those in early ,mid‐pregnant group and control group ,while FIB was significantly higher ,the difference was statistically significant（P〈0 .05） .Conclusion PT ,APTT and FIB can reflect the high blood coagulation state in the late pregnancy ,but can not be used in the diagnosis of early DIC .D‐D and FM have important value for the early diagnosis of DIC in obstetrics .

关 键 词：纤维蛋白单体 D-二聚体 弥散性血管内凝血 孕妇 

分 类 号：R714.254[医药卫生—妇产科学]