类风湿因子、快速C反应蛋白、红细胞沉降率诊断类风湿关节炎的价值  

The role of RF,CRP,ESR in the diagnosis of rheumatoid arthritis

作　　者：朱旭明[1] 丁小青[1] 杨燕[1] 

机构地区：[1]南京医科大学附属无锡人民医院医学检验科,江苏无锡214023

出　　处：《国际检验医学杂志》2015年第20期3007-3008,共2页International Journal of Laboratory Medicine

摘　　要：目的评价类风湿因子(RF)、C反应蛋白(CRP)、红细胞沉降率(ESR)诊断类风湿关节炎(RA)的价值。方法随机选取RA患者74例(RA组),与RA症状相似的非RA患者90例(对照组),检测两组患者的RF、CRP、ESR水平并进行组间比较,用受试者工作特征曲线(ROC)评价这3项指标用于RA诊断的效能。结果 RA组RF、CRP、ESR分别为(271.4±560.9)IU/mL、(28.7±35.6)mg/L、(60.9±40.1)mm/h,均分别高于对照组的(56.8±189.3)IU/mL、(15.4±24.7)mg/L、(45.1±33.1)mm/h;ROC曲线RF、CRP、ESR单独检测以及3项联合检测用于诊断的ROC曲线下面积(AUC)分别为0.784、0.666、0.615、0.757,均有统计学意义(P<0.05)。结论 RF、CRP、ESR在RA诊断中均有一定价值,以RF的诊断效能最高。Objective To investigate the role of rheumatoid factor（RF） ,C‐reactive protein（CRP） ,erythrocyte sedimentation rate （ESR） in the diagnosis of rheumatoid arthritis（RA） .Methods 74 RA patients and 90 patients with symptoms similar to RA were recruited in the study randomly .Blood samples were detected for the levels of RF ,CRP ,ESR .The results were compared between two groups .Receiver operating characteristic curve（ROC） was used to access the diagnostic efficiency .Results The levels of RF , CRP ,ESR of RA group were （271 .4 ± 560 .9）IU/mL ,（28 .7 ± 35 .6）mg/L ,（60 .9 ± 40 .1）mm/h ,respectively ,and were higher than those of control group which were （56 .8 ± 189 .3）IU/mL ,（15 .4 ± 24 .7）mg/L ,（45 .1 ± 33 .1）mm/h respectively .ROC analysis re‐vealed that the AUC of RF ,CRP ,ESR and combined detection of the 3 factors were 0 .784 ,0 .666 ,0 .615 ,0 .757 ,respectively with statistical significance（P〈0 .05） .Conclusion RF ,CRP ,ESR are useful in the diagnosis of RA ,and RF has the highest diagnostic ef f iciency .

关 键 词：类风湿关节炎 类风湿因子 C反应蛋白 红细胞沉降率 

分 类 号：R593.22[医药卫生—内科学]