非编码RNA与增生性瘢痕的研究进展  

Research progress of non-coding RNA in hypertrophic scar

作　　者：李俊[1] 李倩[1] 高艳丽[1] 周蓓[1] 李景云[1] 

机构地区：[1]南京医科大学附属南京妇幼保健院医疗美容科,江苏南京210004

出　　处：《中国美容医学》2015年第20期83-85,共3页Chinese Journal of Aesthetic Medicine

基　　金：江苏省自然科学基金(编号:BK20140083)

摘　　要：增生性瘢痕不仅影响美观,特殊部位的瘢痕还会影响患者的生活质量,给他们带来生理和心理的双重压力。目前,其治疗手段从单纯的手术治疗逐渐转向联合治疗以及基因治疗。近年来,非编码RNA的研究如火如荼,其在增生性瘢痕中的作用亦逐渐被重视,研究非编码RNA有可能为增生性瘢痕的治疗提供新的思路和方向。Hypertrophic scar is a great challenge for the burn and plastic surgery,as it not only affects the appearance,but also affects the quality of life of patients,and brings them physical and psychological pressure.Nowadays there are surgical resection,pressure treatment,local corticosteroid injection and other methods to treat the scar.Combination therapy and gene therapy obtained much more attention.In recent years,studies of non-encoding RNA grow vigorously.The role of non-encoding RNA in hypertrophic scar has attached much more importance.Thus non-coding RNA has the potential to explore hypertrophic scar pathogenesis and resistance mechanisms to provide new ideasand direction.

关 键 词：增生性瘢痕 非编码RNA MICRORNA lncRNA circRNA 

分 类 号：R619.6[医药卫生—外科学]