替加环素对ICU多重耐药革兰阴性菌体外抗菌活性研究  

In-vitro activity of tigecycline against ICU multiple drug-resistant gram-negative pathogens

作　　者：茅国峰[1] 何秋丽[1] 沈少卿[1] 

机构地区：[1]绍兴市人民医院,浙江绍兴312000

出　　处：《中国消毒学杂志》2015年第10期966-969,共4页Chinese Journal of Disinfection

基　　金：浙江省公益技术应用研究项目(2014C33255)

摘　　要：目的研究替加环素对重症监护病房(ICU)分离的多重耐药革兰阴性杆菌的体外抗菌活性,为临床合理用药提供参考。方法通过回顾性分析方法,对某医院ICU送检标本分离的革兰阴性菌体外抗替加环素活性进行调查与分析。结果从ICU分离的革兰阴性病原菌中,选择耐碳青霉烯类药物的大肠埃希菌(11株)、肺炎克雷伯菌(60株)和鲍曼不动杆菌(118株)进行替加环素抗性试验,结果显示对替加环素的敏感率依次为100.0%、93.3%和89.0%。结论替加环素对ICU分离的多重耐药革兰阴性杆菌具有很好的体外抗菌活性,可作为临床用药选择依据。Objective To investigate in-vitro activity of tigecycline against multi-drug resistant gram-negative bacteria in Intensive Care Unit（ ICU） for clinical rational medication. Methods Retrospective survey was used to analyze the activity of tigecycline in vitro of gram negative bacteria of ICU specimens in a hospital. Results Among the gram-negative pathogens isolated from ICU,Escherichia coli resistant to carbapenem drugs（ 11 strains）,Klebsiella pneumoniae（ 60strains） and Bauman Acinetobacter（ 118 strains） were chosen for tigecycline resistance test. The sensitive rates of the carbapenems were 100%,93. 3% and 89. 0% respectively. Conclusion Tigecycline maintains a good in vitro-antibacterial activity against multi-drug resistant gram-negative bacteria in ICU,which can be used as the basis for the clinical medication.

关 键 词：替加环素 革兰阴性菌 抗菌活性 多重耐药菌 

分 类 号：R378[医药卫生—病原生物学]