鸽副黏病毒油乳剂灭活疫苗不同水油比的研究  

Study on the pigeon paramyxovirus inactivated vaccine of different water/oil ratio

作　　者：蒋凤英[1] 张俊平[1] 何锡忠[1] 张春玲[1] 李春华[1] 周宗清[1] 杨惠萍[1] 倪建平[1] 

机构地区：[1]上海市农业科学院畜牧兽医研究所,上海201106

出　　处：《上海农业学报》2015年第5期27-31,共5页Acta Agriculturae Shanghai

基　　金：上海市科委科技支撑项目(1339192000)

摘　　要：为了减少鸽副黏病毒油乳剂灭活疫苗的副作用,保证疫苗的安全性及免疫效果,利用分离到的鸽Ⅰ型副黏病毒(S-1株)作为抗原,配制了不同水油比的疫苗,对疫苗的物理性状、安全性、效力试验及免疫效果进行观察,探究疫苗不同水油比的差异。结果表明:该疫苗的水油乳化比为1:4时,疫苗的稳定性最好、免疫效果最佳。In order to reduce the side-effects of pigeon paramyxovirus oil emulsion inactivated vaccine and ensure the safety and immune effect of vaccine,the isolated pigeon paramyxovirus S-1 strain was used as the antigen to prepare with different water/oil ratio.The physical characteristics,safety,efficacy and immune effect of the vaccine were observed to explore the vaccine differences of different water/oil ratio.The results indicated that the vaccine has the best stability and immune effect when the water/oil ratio is 1：4.

关 键 词：鸽副黏病毒 油乳剂灭活疫苗 水油比 

分 类 号：S858.28[农业科学—临床兽医学]