左氧氟沙星联合盐酸坦索罗辛及宁泌泰治疗慢性前列腺炎的疗效观察  

Curative effect of Levofloxacin tablets combined with Tamsulosin and Ningbitai for the treatment of chronic prostatitis

作　　者：马强[1] 贾国金[1] 金伟[1] 陆雪强[1] 陈卓[1] 谢雪锋[1] 

机构地区：[1]复旦大学附属金山医院泌尿外科,上海201508

出　　处：《中国性科学》2015年第10期11-13,共3页Chinese Journal of Human Sexuality

基　　金：上海市科学技术委员会科研计划项目(124119a3302)

摘　　要：目的:探讨左氧氟沙星联合盐酸坦索络辛及宁泌泰治疗慢性前列腺炎的疗效。方法:2013年1月至2014年8月,应用前瞻性随机平行对照研究将355例慢性前列腺炎患者随机分成A、B,C,D 4组,A组:左氧氟沙星联合盐酸坦索罗辛及宁泌泰89例;B组:左氧氟沙星和盐酸坦索罗辛88例;C组:左氧氟沙星联合宁泌泰87例;D组:左氧氟沙星91例。4种方法各治疗6周,记录治疗前后慢性前列腺炎症状指数(NIH-EPSI)评分及前列腺液白细胞数目,并且比较治疗前后4种疗法的疗效。结果:4组治疗前NIH—CPSI评分及前列腺液白细胞数目等基线资料比较差异均无统计学意义(P>0.05)。A组治疗前后NIH-CPSI评分为(24.34±4.65)和(13.72±5.22)分;前列腺液白细胞数目为(15.34±3.34)个和(7.08+2.26)个/HP,治疗前后比较差异均有统计学意义(P<0.01)。A组与其他3组治疗后NIH-CPSI比较差异有统计学意义(P<0.01),而前列腺液白细胞计数比较差异无统计学意义(P>0.05)。4组患者均未报告不良事件。结论:左氧氟沙星联合盐酸坦索络辛及宁泌泰治疗慢性前列腺炎疗效满意,有良好的安全性和耐受性。Objectives： To evaluate the efficacy of Levofloxacin tablets combined with Tamsulosin and Ningbitai for the treatment of chronic prostatitis. Methods： From January 2013 to August 2014,355 patients were included in this prospective study. All the 355 patients were randomly divided into 4 groups（ A,B,C,D） ： 89 patients received Levofloxacin tablets combined with Tamsulosin and Ningbitai; 88 patients received Levofloxacin tablets and Tamsulosin; 87 patients were treated with Levofloxacin tablets and Ningbitai; 91 patients were treated with Levofloxacin tablets only. NIH- chronic Prostatitis symptom index（ NIH- CPSI） and white blood cell（ WBC）counts in expressed prostate secretion（ EPS） were evaluated before and 6 weeks after the treatment. The results of the four groups were compared. Results： Before the treatment,there was no significant difference in the（ NIH-CPSI） and white blood cell（ WBC） counts among the 4 groups. The NIH—CPSI（ 24. 34 ± 4. 65 versus 13. 72 ±5. 22） and EPS WBC count（ 9. 75 ± 2. 24 versus 9. 08 ± 2. 26） significantly decreased in group A after 6 weeks of treatment（ P〈0. 01）. The NIH- CPSI in group A after treatment was significantly lower than those in the other three groups（ P〈0. 01）,but there was no significant difference in EPS WBC count among the 4 groups（ P〈0. 05）. All patients in the 4 groups did not report diverse events. Conclusion： The use of levofloxacin tablets combined with tamsulosin and ningbitai can improve the symptoms for patients,which is safe and effective in the treatment of chronic prostatitis.

关 键 词：慢性前列腺炎 左氧氟沙星 坦索罗辛 宁泌泰 

分 类 号：R983[医药卫生—药品]