心肌致密化不全五例并文献复习  

Noncompaction of ventricular myocardium：five case report and literature review

作　　者：贡旭楠[1] 王永杰[1] 邬志强[1] 

机构地区：[1]吉林省人民医院重症医学科,吉林省长春市130021

出　　处：《中国心血管病研究》2015年第10期952-955,共4页Chinese Journal of Cardiovascular Research

摘　　要：目的 探讨心肌致密化不全的临床特点,以提高对该病的认识.方法 对5例心肌致密化不全患者的临床资料及治疗方法进行分析并复习相关文献.结果 5例患者发病年龄19～78岁,其中3例表现为呼吸困难,2例表现为心律失常.5例患者均通过超声心动图诊断为心肌致密化不全.治疗方案遵循慢性心衰指南.治疗结果：1例因非心源性因素死亡;4例出院,维持心功能Ⅲ～Ⅳ级,随访中.结论 心肌致密化不全较为罕见,伴有多种并发症,包括心力衰竭、休克、心律失常甚至猝死.可通过超声心动图进行诊断,依据慢性心衰指南进行治疗.其发病机制和治疗方法仍需进一步研究.Objective To summaries the clinical features of noncompaction of ventricular myocardium, and improve the recognition of this disease. Methods The clinical data of five patients with noneompaetion of ventricular myocardium were analyzed and the related literature was reviewed. Results The patients aged from 19 to 78 years, shortness of breath was present in 3 eases, the other 2 patients suffered from arrhythmias at presentation. All these 5 patients were diagnosed by eehoeardiography. LV systolic dysfunction or symptomatic HF was treated according to established guidelines. Therapeutic outcome：l patient died from noncardiovascular causes, 4 patients were discharged with NYHA functional class Ⅲ- Ⅳsymptoms, and still been followed up. Conclusion LVNC in adults is a rare disease with serious complications, including HF, stroke, arrhythmia, and death. It can be diagnosed by echocardiography. LV systolic dysfunction or symptomatic HF should be treated according to established guidelines. Further investigation of pathogenesis and therapeutic strategies of this rare disease was warranted.

关 键 词：心肌致密化不全 心力衰竭 血栓栓塞 心律失常 

分 类 号：R542.2[医药卫生—心血管疾病]