时间药理学用药干预对老年慢性阻塞性肺疾病患者治疗效果的影响  

The Effect of Time Pharmacological Intervention on Chronic Obstructive Pulmonary Disease in the Elderly Patients

作　　者：陈金云[1] 吴晶[1] 蒋志红[1] 陈咏梅[1] 

机构地区：[1]海军总医院呼吸内科,北京100048

出　　处：《医学综述》2015年第20期3806-3808,共3页Medical Recapitulate

摘　　要：目的观察时间药理学用药干预在老年慢性阻塞性肺疾病(COPD)患者治疗中的作用。方法 2013年1月至2014年1月将海军总医院呼吸内科收治的104例老年COPD患者按随机数字表法分为观察组和对照组,各52例。对照组以患者意愿自行安排用药时间,观察组按所服药物的时间药理学特点进行用药干预,比较两组患者的急性再发作率和肺功能指标。结果观察组总有效率为98.1%(51/52),高于对照组的86.5%(45/52),差异有统计学意义(P<0.05);观察组急性再发作率为28.8%,2次以上急性再发作率为7.7%,均低于对照组(48.1%,23.1%),差异有统计学意义(P<0.05);治疗后观察组第1秒用力呼气量/用力肺活量比、第1秒用力呼气量、动脉血氧分压均高于对照组[(71±4)%比(64±6)%,(72±9)%比(65±11)%,(73±8)mm Hg(1 mm Hg=0.133 k Pa)比(69±7)mm Hg,P<0.05或P<0.01],动脉血二氧化碳分压低于对照组[(42±8)mm Hg比(45±7)mm Hg,P<0.05]。结论时间干预治疗模式有助于改善老年COPD患者肺功能,降低急性再发作率,值得临床重视。Objective To investigate the effect of time pharmacological intervention on chronic obstruc- tive pulmonary disease（COPD） in the elderly patients. Methods From Jan. 2013 to Jan. 2014,104 elderly patients with COPD from the Respiratory Medicine, Navy General Hospital were divided into observation group and control group with 52 cases in each group according to random number table method. The control group was given conventional time of medication at the patients＇ will, while the observation group received treatment interventions according to the medication＇s time pharmacological characteristics. The acute recur- rent rate and pulmonary function were compared between the two groups. Results The total effective rate in the observation group was 98.1% （51/52） ,which was higher than the control group＇s 86.5% （45/52） （P 〈 D. 05 ）. The acute recurrent rate of the observation group was 28.8%, more than 2 times of acute recurrent rate was 7.7% ,they were all lower than the control group which were 48.1% and 23.1% （ P 〈 0.05 ）. In the observation group the forced expiratory volume in one second/forced vital capacity, forced expiratory vol- ume in one second,arterial oxygen partial pressure were higher than those in the control group[ （71 ±4）% vs （64±6）%,（72 ±9）% vs （65 ±11）% ,（73 ±8） mmHg vs （69 ±7） mmHg,P 〈0. 05 orP〈0.01], arterial oxygen partial pressure was lower than in the control group [ （ 42 ± 8 ） mmHg vs （45 ± 7 ） mmHg, P 〈 0.05 ]. Conclusion Time pharmacological intervention can improve the pulmonary function in elderly patients with COPD, and reduce the rate of recurrent acute attack, which is worthy of attention in clinical.

关 键 词：慢性阻塞性肺疾病 时间药理学 疗效 肺功能 

分 类 号：R563.1[医药卫生—呼吸系统]