伤科黄水对消肿祛腐期糖尿病足抗氧化作用的研究  

Study on anti-oxidation effects of Trauma Yellow-Water on eliminating swelling and removing slough stage of diabetic foot

作　　者：吴英[1] 黄慧萍[1] 林旋[1] 张劲丰[1] 苏荣[1] 梁敏华[1] 

机构地区：[1]佛山市中医院,广东528000

出　　处：《现代医药卫生》2015年第21期3227-3229,共3页Journal of Modern Medicine & Health

基　　金：2012年佛山市医学类科技攻关项目(201208085)

摘　　要：目的探讨伤科黄水对消肿祛腐期糖尿病足(DF)患者伤口溃疡的抗氧化作用。方法将2012年9月至2014年12月该院收治的60例DF患者分为对照组和观察组,每组30例。对照组采用常规换药,无菌纱布填充,加压弹力绷带包扎;观察组采用外敷伤科黄水治疗。检测两组患者治疗第7、14天溃疡组织核因子-κB(NF-κB)m RNA灰度比值,白介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)水平。结果治疗第7、14天,对照组NF-κB m RNA灰度比值分别为1.52、1.51,观察组为1.30、1.14,两组比较,差异均有统计学意义(P<0.05)。观察组治疗第14天时NF-κB m RNA灰度比值与治疗第7天比较,差异无统计学意义(P>0.05)。治疗第7、14天,观察组IL-1β、TNF-α水平与对照组比较,差异均有统计学意义(P<0.05)。结论伤科黄水治疗消肿祛腐期DF伤口溃疡可抑制NF-κB m RNA的表达,降低细胞因子IL-1β、TNF-α水平,具有抗氧化作用。Objective To investigate the anti-oxidation effects of Trauma Yellow-Water on the wound ulcer in the patients with eliminating swelling and removing slough stage of diabetic foot（DF）. Methods 60 cases of DF in our hospital from September 2012 to December 2014 were divided into the control group and the observation group,30 cases in each group. The control group adopted the conventional dressing change,sterile gauze filling and pressurized elastic bandaging,while the observation group adopted the external application of Trauma Yellow-water. The m RNA gray level ratio of the nuclear factor-κB（NF-κB）,IL-1β and TNF-α levels in ulcer tissue on 7,14 d of treatment were detected in the two groups. Results The NF-κB m RNA gray level ratios on 7,14 d of treatment in the control group were 1.52 and1.51,which in the observation group were 1.30 and 1.14 re spectively,the differences between the two groups were statistically significant（P〈0.05）. The NF-κB m RNA gray level ratios had no statistical difference between on 7 d of treatment and on 14 d of treatment（P〉0.05）. The levels of IL-1β and TNF-α. on 7,14 d of treatment had statistical difference between the two groups（P〈0.05）. Conclusion Trauma Yellow-Water for treating wound ulcer in the patients with eliminating swelling and removing slough stage of DF can inhibit the expression of NF-κB m RNA,reduces the levels of cytokine IL-1β and TNF-α with the anti-oxidation effect.

关 键 词：伤科方 糖尿病足/中药疗法 足溃疡 氧化性应激 消肿 祛腐生肌 

分 类 号：R285.5[医药卫生—中药学]