高b值磁共振扩散加权成像在脑泡型包虫病边缘带的研究  

The primary study of high b-value in the diffusion weighted magnetic resonance imaging on the edge of cerebral alveolar echinococcosis

作　　者：高丽娟[1] 巴哈提.哈立亚 王俭[1] 姜春晖[1] 马娟[1] 柳琛[2] 

机构地区：[1]新疆医科大学第一附属医院影像中心,乌鲁木齐830054 [2]新疆医科大学第一附属医院神经外科,乌鲁木齐830054

出　　处：《新疆医科大学学报》2015年第11期1339-1342,共4页Journal of Xinjiang Medical University

基　　金：国家自然科学基金(30860268);新疆维吾尔自治区自然科学基金(2011211A072)

摘　　要：目的探讨不同b值DWI的定量指标ADC值对脑泡型包虫病边缘带的研究价值。方法收集2009年7月-2014年6月15例经病理诊断（8例）和临床诊断（7例）的CAE患者（共35个有效病灶）;应用GE singa HDX3.0T超导磁共振仪,分别进行全脑常规MR平扫、增强扫描及DWI检查,DWI梯度敏感因子b值取1 000s/mm^2和3 000s/mm^2两组。分别测量病灶实质区、病灶周边0-10 mm范围内脑实质区（灶周0-10mm）、病灶周边10-20mm（灶周10-20mm）范围内脑实质区及对侧相应正常区域的脑的ADC值,并进行统计学分析。结果灶周水肿在T1WI上表现为低信号,在T2WI上呈高信号,T2Flair序列上呈高信号,病灶实质在b=1 000s/mm^2的ADC图上呈低信号,灶周水肿呈更低信号。病灶实质在b=3 000s/mm^2的ADC图上呈低信号,灶周水肿呈更低信号,境界显示较b=1 000s/mm^2更清晰。b值为1 000及3 000s/mm^2时,病灶实质区与灶周0-10mm区ADC值比较差异无统计学意义（P〉0.05）;b值为1 000及3 000s/mm^2时,病灶实质区、灶周10-20mm区及对照区ADC值两两比较,差异均有统计学意义（P〈0.05）。结论 b值为1 000及3 000s/mm^2,病灶区与0-10mm区ADC值具有同质性,提示CAE病灶边缘带存在泡状棘球蚴浸润。高b值ADC可以反映CAE不同区域特征,并且有助于推测CAE浸润范围,为临床手术方案的制定及预后分析提供客观的影像学依据。Objectives To investigate the significance of different b value Diffusion Weighted Imaging（DWI）ADC in marginal zone of Cerebral Alveolar Echinococcosis（CAE）.Methods 15 cases of pathologically diagnosed（8cases）and clinically diagnosed（7cases）CAE patients（35focal areas in total）from July,2009 to June,2014 were collected.GE singa HDx 3.0T MRI was used to perform regular MR scan,enhanced sand and DWI scan.B value,the gradient sensitive factor,was set at 1 000s/mm^2 and 3 000s/mm^2 respectively to measure the ADC of the solid area of focal area,0-10 mm around the focal area（0-10 mm area）,10-20 mm around the focal area（10-20 mm area）and offside normal area ADC.Results When b=1 000 and 3 000s/mm^2,ADC difference between focal area and 0-10 mm area does not show statistic significance（P 0.05）;when b=1 000 and 3 000s/mm^2,ADC shows statistically significant difference among focal area,10-20 mm area and control group,compared in pairs（P 0.05）;when b=1 000 and 3 000s/mm^2,ADCs of the focal area and 0-10 mm area show homogeneity,indicating Alveolar hydatid cyst infiltration around the CAE focal area.Conclusion High b value ADC can reflect features of difference areas of CAE and contributes to speculate the scope of CAE infiltration,which can provide objective imaging evidences for clinical operation planning and post-intervention analysis.

关 键 词：棘球蚴病 脑 磁共振扩散加权成像 边缘带 

分 类 号：R445.2[医药卫生—影像医学与核医学]