磁共振扩散加权成像ADC、EADC脑泡型包虫病边缘带定量分析  

Quantitative analyze the ADC and EADC of diffusion weighted magnetic resonance imaging for the edge of cerebral alveolar echinococcosis

作　　者：马娟[1] 王金英[1] 王俭[1] 姜春晖[1] 鲁君[1] 罗坤[2] 柳琛[2] 

机构地区：[1]新疆医科大学第一附属医院影像中心,乌鲁木齐830054 [2]新疆医科大学第一附属医院神经外科,乌鲁木齐830054

出　　处：《新疆医科大学学报》2015年第11期1347-1350,共4页Journal of Xinjiang Medical University

基　　金：国家自然科学基金(30860268);新疆维吾尔自治区自然科学基金(2011211A072)

摘　　要：目的探讨磁共振扩散加权成像（DWI）定量指标ADC、EADC在脑泡型包虫病边缘带研究中的应用价值。方法收集2009年7月-2013年3月11例经新疆医科大学第一附属医院临床诊断为CAE患者共23个病灶;应用GESinga HDX 3.0T超导磁共振仪,分别进行全脑常规MR平扫、增强扫描及DWI检查,DWI梯度敏感因子b值取1 000s/mm2。测量CAE病灶内部（病灶实质区）、0-10mm边缘区、10-20mm边缘区及对侧相应部位的脑实质区（对照区）表观扩散系数（apparent diffusion coefficient ADC）、指数表观扩散系数（exponential apparent diffusion coefficient EADC）,并进行统计学分析。结果脑病灶实质区、边缘区ADC值高于对照区,远离CAE病灶实质区ADC值逐渐升高,EADC值逐渐降低。病灶实质区、边缘区与对照区ADC值比较差异有统计学意义（P〈0.05）;10-20mm边缘区与病灶实质区、0-10mm边缘区ADC、EADC值比较差异有统计学意义（P〈0.05）;0-10 mm边缘区与病灶实质区ADC值比较差异无统计学意义。结论 DWI技术可以反映并评价CAE病灶实质及边缘带区域特征,此不仅有助于手术前CAE的鉴别诊断,并且有助于界定CAE浸润带范围,为临床手术方案的制定及预后分析提供客观的影像学依据。Objective To investigate the magnetic resonance diffusion weighted imaging（DWI）quantitative indicators ADC,EADC in the study of cerebral alveolar echinococcosis marginal zone.Methods Collected11cases（23lesions）diagnosed as cerebral alveolar echinococcosis during July,2009-March,2013 in our hospital,and applied 3.0Tsuperconductive MRI apparatus to conduct whole brain conventional MR scan,enhanced scan,multi-voxel 1 H-MRS and DWI checks,DWI gradient sensitive factor b value were chosen1 000s/mm2.The apparent diffusion coefficient（ADC）,exponential apparent diffusion coefficient（EADC）in CAE lesion parenchyma,0-10 mm edema,10-20 mm edema and the contralateral corresponding parts of the brain parenchyma（control zone）were measured.Results ADC values in parenchyma,marginal zone were higher than the control zone,and gradually increased away from CAE parenchyma lesions,while EADC values gradually lower.The differences of ADC and EADC values in Parenchyma lesions,marginal zone compared to the control zone were statistically significant（P 〈0.05）;the differences of ADC in between 10-20 mm marginal lesion parenchyma and 0-10 mm marginal,was statistically significant（P 〈0.05）;the differences of ADC and EADC in between 0-10 mm marginalzone and parenchyma was not statistically significant.Conclusion DWI technique can reflect and evaluate CAE feature in lesion parenchyma and marginal zone,which could not only contribute to differential diagnosis of CAE before surgery,but define the range of CAE infiltration zone,that will provider objective imaging evidences for establishing the surgery plan and prognosis analyzing.

关 键 词：泡型包虫病 脑 脑磁共振扩散加权成像 边缘带 

分 类 号：R445.2[医药卫生—影像医学与核医学]