基于CT、MR测量肝脏脂肪含量的动物实验研究  

Experimental study of measurement of liver fatty content by CT and MR imaging technology

作　　者：黄玉洁[1] 赵建卿[1] 王健[1] 迪里木拉提.巴吾东 刘文亚[1] 

机构地区：[1]新疆医科大学第一附属医院影像中心,乌鲁木齐830054

出　　处：《新疆医科大学学报》2015年第11期1413-1416,1419,共5页Journal of Xinjiang Medical University

基　　金：新疆医科大学第一附属医院院内基金(2011YFY10)

摘　　要：目的探讨CT值、磁共振氢质子波谱、磁共振三点式水脂分离(IDEAL)技术评估肝脏脂肪含量的价值。方法选取新疆医科大学第一附属医院动物中心同种成年Beagle犬15只。高脂饮食饲养后同期进行肝脏CT平扫、磁共振氢质子波谱及IDEAL成像;测量肝脏同一部位CT值、1 H MRS脂/水峰高度及峰下面积和IDEAL脂/水信号比值;比较不同诊断方法的一致性。6只实验动物获得病理标本测量肝脏脂肪含量,评价3种影像方法与病理结果的相关性。结果在几种检测指标中,肝/脾CT比值与1 H MRS脂/水峰高和峰下面积比值呈显著负相关(相关系数r分别为-0.74、-0.85,P<0.01),与病理结果对比,肝/脾CT比值、1 H MRS脂/水峰高及峰下面积比值与病理结果相关性较高(r分别为-0.943、0.886、0.943,P值分别为0.005、0.019、0.005),而IDEAL脂/水信号比值与病理结果无明显相关性(r=0.771,P=0.072)。结论 CT、1 H MRS与病理结果有较显著的相关性,为临床定量分析肝脂肪含量较可靠的方法;磁共振IDEAL技术与病理及其他影像检查的一致性较低。Objective To evaluate the consistency of computed tomography（CT）,1 H MR spectroscopy（1 H MRS）and Iterative decomposition of water and fat with echo asymmetry and least-squares estimation（IDEAL）in liver fat content detection.Methods 15 homogeneity high-fat die Beagle dogs were enrolled in the study,all which underwent plain CT scan,Single Voxel 1 H MRS analysis and IDEAL imaging synchronously.The variable indexes including the CT values,the 1 H MRS peaks of H2 O and lipid,the areas under the peaks,the fat and water signal values of IDEAL were measured,and with correlation analysis.6of these dogs also were conducted pathological contrast.Results All the above indexes,there are negative correlations existing between the CT value ratio and the areas under the 1 H-MRS peaks ratio（r=-0.743,P 〈0.01）,also between CT value ratio and 1 H-MRS peaks ratio（r=-0.850,P 〈0.01）.Compared with the pathologic results,the correlation coefficients were-0.943（P =0.005）,0.886（P =0.019）,0.943（P =0.005）respectively.Conclusion There are significant relationships among CT,1 H-MRS and pathology,and which are reliable methods for quantitative detecting of fatty liver.In this experiment,the IDEAL water-fat separate technique has no obvious correlation with pathology and other imaging techniques.

关 键 词：磁共振成像 肝脏 脂肪测定 一致性评价 

分 类 号：R445[医药卫生—影像医学与核医学]