天疱疮患者头发毛囊直接免疫荧光检测及其临床意义探讨  

The Detection and Clinical Significance of Direct Immunofluorescence of Antibodies in the Follicles of Patients with Pemphigus

作　　者：来学民[1] 赵玉铭[2] 王雅坤[2] 

机构地区：[1]沈阳市第七人民医院皮肤科,辽宁沈阳110003 [2]中国医科大学附属第一医院皮肤科,辽宁沈阳110001

出　　处：《中国皮肤性病学杂志》2015年第11期1134-1136,共3页The Chinese Journal of Dermatovenereology

摘　　要：目的评价天疱疮患者头发毛囊直接免疫荧光检测的临床意义。方法每例患者头发约20根,采取直接染色方法进行直接免疫荧光检查。结果天疱疮患者毛囊直接免疫荧光示FITC标记的羊抗人IgG抗体在毛囊表皮下的外毛根鞘呈网状沉积,其荧光强度与天疱疮患者病情严重程度呈正相关(r=0.505,P<0.05)。随访也发现,病情波动,毛囊DIF强度也随之变化,二者呈正相关。结论天疱疮患者毛囊直接免疫荧光强度在一定程度上反映与病情严重程度的相关性,推断对其强度的监测可用于评价疾病的严重程度并指导临床治疗。Objective To investigate the clinical significance of direct immunofluorescence（DIF） of follicles of plucked hair in pemphigus. Method Hairs with follicles were stained by direct immunofluorescence. Results Intensity of DIF in the follicles showed positive correlated with the disease severity （ r = 0. 505, P 〈 0. 05 ）. Conclusion Intensity of DIF in the follicles showed positive correlated with the disease severity to some extent. The repeated examination of DIF in the follicles of plucked hair from patients with pemphigus may be a utility method for guiding clinical therapy.

关 键 词：天疱疮 抗体 毛囊 外毛根鞘 免疫荧光 

分 类 号：R758.66[医药卫生—皮肤病学与性病学]