氯波必利生物黏附型缓释片对实验性胃溃疡和胃肠动力障碍的作用研究  

Study on Effects of Clebopride Bioadhesive Sustained-release Tablets on Experimental Gastric Ulcer and Gastrointestinal Motility Disorder

作　　者：曾春莲[1,2] 徐雄波[1] 张青松[1] 刘鹰 刘卫平[1] 马宁[1] 

机构地区：[1]长沙医学院药学院,长沙410219 [2]湖南正清制药集团股份有限公司,湖南怀化418005 [3]湖南九典制药有限公司,湖南浏阳410331

出　　处：《中国药房》2015年第31期4351-4353,共3页China Pharmacy

基　　金：湖南省科技厅科学计划项目(No.2012SK3104);2014年省级药学类专业校企合作人才培养示范基地项目(No.湘教通〔2014〕272号)

摘　　要：目的：研究氯波必利（CBP）生物黏附型缓释片对实验性胃溃疡和胃肠动力障碍的作用。方法：取大鼠以乙醇＋阿司匹林法复制胃溃疡模型后,分为模型（生理盐水）组、普通片（CBP片0.072 mg/kg）组和缓释片高、低剂量（CBP生物黏附型缓释片0.072、0.036 mg/kg）组,另取正常大鼠为正常对照（生理盐水）组;除缓释片组每日ig药物2次外,其余组每日给药3次,给药第2、4天后解剖观察溃疡面积,计算溃疡愈合率（n=6）。取小鼠以阿托品复制胃肠动力障碍模型后,分为模型（生理盐水）组、普通片（CBP片0.1 mg/kg）组和缓释片高、中、低剂量（CBP生物黏附型缓释片0.1、0.05、0.025 mg/kg）组,另取正常小鼠为正常对照（生理盐水）组,每日ig药物1次,连续3 d,检测小鼠胃排空率和小肠推进率（n=6）。结果：与正常对照组比较,模型组大鼠溃疡面积增加;与模型组比较,普通片组和缓释片高、低剂量组大鼠溃疡面积减小,差异有统计学意义（P〈0.01）,给药2 d的愈合率为32.35%~48.24%,给药4 d的愈合率均超过70%。与正常对照组比较,模型组小鼠胃排空率和小肠推进率降低;与模型组比较,普通片组和缓释片高、中、低剂量组小鼠胃排空率和小肠推进率升高,其中缓释片高、中剂量组作用效果强于普通片组,以上差异均有统计学意义（P〈0.01或P〈0.05）。结论：CBP生物黏附型缓释片对大鼠胃溃疡和小鼠胃肠动力障碍均有改善作用。OBJECTIVE：To study the effects of Clebopride（CBP）bioadhensive sustained-release tablets on experimental gastric ulcer and gastrointestinal motility disorder. METHODS：Gastric ulcer rat model was induced by ethanol and aspirin,and then divided into model group（normal saline）,common tablet（CBP tablet 0.072 mg/kg） and sustained-release tablet high-dose and low-dose groups（CBP bioadhensive sustained-release tablet 0.072,0.036 mg/kg）;normal rats were included in normal control group（normal saline）;they were given relevant medicine intragastrically,twice a day for sustained-release tablet,three times a day for other. Ulcer area were observed 2 and 4 days after medication to calculate healing rate of ulcer（n=6）. Gastrointestinal motility disorder mice model was induced by atropine,and then divided into model group（normal saline）,common tablet group（CBP tablet 0.1 mg/kg）and sustained-release tablet high-dose,medium-dose and low-dose groups（CBP bioadhensive sustained-release tablet 0.1,0.05,0.025 mg/kg）;normal mice were included in normal control group（normal saline）;they were given relevant medicine intragastrically,once a day,for consecutive 3 days. The rate of gastric emptying and small intestinal propulsion were detected（n=6）. RESULTS：Compared with normal control group,ulcer area of rats increased in model group;compared with model group,that of rats decreased in common tablet group and sustained-release tablet high-dose,low-dose groups,with statistical significance（P〈0.01）;healing rates of gastric ulcer were 32.35%-48.24% 2 days after medication,and those were above70% 4 days after medication. Compared with normal control group,the rate of gastric emptying and small intestinal propulsion in mice decreased in model group;compared with model group,those of mice increased in common tablet group and sustained-release tablet high-dose,medium-dose,low-dose groups. The effects of sustained-release tablet high-dose and medium-dose groups were better than that of common t

关 键 词：氯波必利 生物黏附型缓释片 胃溃疡 胃肠动力障碍 大鼠 小鼠 

分 类 号：R965[医药卫生—药理学]